ArticleAntimicrobial agents and chemotherapy2008
Comparison of the in vitro efficacies of moxifloxacin and amoxicillin against Listeria monocytogenes.
Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- A viral uveitis masquerade: PCR-confirmed Listeria monocytogenes necrotizing chorioretinitis complicated by secondary macular hole.Journal of ophthalmic inflammation and infection · 2026Article
- BRMDA: prediction model for potential microbe-drug associations based on bilinear attention networks and random forest.Frontiers in genetics · 2026Article
- Occurrence of Antimicrobial-ResistantVeterinary medicine international · 2026Article
- Hybrid Genome Sequencing and Comparative Analysis of Three NovelFoods (Basel, Switzerland) · 2025Article
- Listeriosis.Nature reviews. Disease primers · 2025Review
- Genomic characterization ofMicrobial genomics · 2025Article
- Clinical Presentations and Nosocomial Infections of Neurolisteriosis.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025Review
- Maternal-Fetal Listeriosis in China: Clinical and Genomic Characteristics From an ST8Infection and drug resistance · 2025Article
- Clinical and Genomic Characteristics of a Clinical Listeria Monocytogenes ST120 Isolate Recovered from a Pregnant Woman.Infection and drug resistance · 2024Article
- Human Listeriosis.Clinical microbiology reviews · 2023Review
- Treatment ofIDCases · 2023Article
- Diversity of Listeria monocytogenes Strains of Clinical and Food Chain Origins in Belgium between 1985 and 2014.PloS one · 2016Article
- Discrete and overlapping functions of peptidoglycan synthases in growth, cell division and virulence of Listeria monocytogenes.Molecular microbiology · 2015Article
- High-performance liquid chromatography assay for moxifloxacin in brain tissue and plasma: validation in a pharmacokinetic study in a murine model of cerebral listeriosis.Journal of analytical methods in chemistry · 2012Article
- Impact of a low-oxygen environment on the efficacy of antimicrobials against intracellular Chlamydia trachomatis.Antimicrobial agents and chemotherapy · 2011Article
- [Listeriosis in adults - case reports and review of the literature].Wiener klinische Wochenschrift · 2010Review
- Cooperation between prokaryotic (Lde) and eukaryotic (MRP) efflux transporters in J774 macrophages infected with Listeria monocytogenes: studies with ciprofloxacin and moxifloxacin.Antimicrobial agents and chemotherapy · 2008Article
- Rapid eradication of Listeria monocytogenes by moxifloxacin in a murine model of central nervous system listeriosis.Antimicrobial agents and chemotherapy · 2008Article
- The use of Listeria monocytogenes as a DNA delivery vector for cancer gene therapy.Bioengineered bugsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Listeria monocytogenes is a facultative intracellular bacterium that causes severe infections associated with a high mortality rate. Moxifloxacin presents extended activity against gram-positive bacteria and has recently been suggested to be a potential alternative in the treatment of listeriosis. We evaluated the in vitro efficacy of moxifloxacin against L. monocytogenes using a combination of epidemiological and experimental approaches. The median MIC of moxifloxacin for a large collection of L. monocytogenes strains of various origins (human, food, and environment) was 0.5 microg/ml (MIC range, 0.064 to 1 microg/ml). No differences were observed, irrespective of the origin of the strains. Moreover, no cross-resistance with fluoroquinolones was detected in strains that have been reported to be resistant to ciprofloxacin. The in vitro activities of moxifloxacin and amoxicillin were compared by time-kill curve and inhibition of intracellular growth experiments by using a model of bone marrow-derived mouse macrophages infected by L. monocytogenes EGDe. Both moxifloxacin and amoxicillin were bactericidal in broth against extracellular forms of L. monocytogenes. However, moxifloxacin acted much more rapidly, beginning to exert its effects in the first 3 h and achieving complete broth sterilization within 24 h of incubation. Moxifloxacin has a rapid bactericidal effect against intracellular reservoirs of bacteria, whereas amoxicillin is only bacteriostatic and appears to prevent cellular lysis and the subsequent bacterial spreading to adjacent cells. No resistant bacteria were selected during the in vitro experiments. Taken together, our results suggest that moxifloxacin is an interesting alternative to the reference treatment, combining rapid and bactericidal activity, even against intracellular bacteria.
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