ArticleThe Journal of biological chemistry2008
Sorting of the neuroendocrine secretory protein Secretogranin II into the regulated secretory pathway: role of N- and C-terminal alpha-helical domains.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 53 citations in OpenAlex.
- Detecting the body's reproductive hormonal brake against tissue overgrowth: Micrin/SgII-70.PloS one · 2026Article
- Hippocampal gray matter volume alterations in patients with first-episode and recurrent major depressive disorder and their associations with gene profiles.BMC psychiatry · 2025Article
- Estrogen-dependent expression and function of secretogranin 2a in female-specific peptidergic neurons.PNAS nexus · 2023Article
- Forty years of the adrenal chromaffin cell through ISCCB meetings around the world.Pflugers Archiv : European journal of physiology · 2023Review
- Endocrine secretory granule production is caused by a lack of REST and intragranular secretory content and accelerated by PROX1.Journal of molecular histology · 2022Article
- Hexapeptides from mammalian inhibitory hormone hunt activate and inactivate nematode reproduction.PloS one · 2022Article
- Inside the Insulin Secretory Granule.Metabolites · 2021Review
- Differential sorting behavior for soluble and transmembrane cargoes at theMolecular biology of the cell · 2020Article
- Efficient gene transfers into neocortical neurons connected by NMDA NR1-containing synapses.Journal of neuroscience methods · 2019Article
- Separate Gene Transfers into Pre- and Postsynaptic Neocortical Neurons Connected by mGluR5-Containing Synapses.Journal of molecular neuroscience : MN · 2019Article
- Epitope mapping of an uncertain endogenous antigen implies secretogranin II peptide splicing.F1000Research · 2019Article
- Delivery of different genes into pre- and post-synaptic neocortical interneurons connected by GABAergic synapses.PloS one · 2019Article
- Identification of novel loci affecting circulating chromogranins and related peptides.Human molecular genetics · 2017Article
- Mysterious inhibitory cell regulator investigated and found likely to be secretogranin II related.PeerJ · 2017Article
- Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system.BMC medical genetics · 2016Article
- Differential Reovirus-Specific and Herpesvirus-Specific Activator Protein 1 Activation of Secretogranin II Leads to Altered Virus Secretion.Journal of virology · 2015Article
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- Targeted gene transfer of different genes to presynaptic and postsynaptic neocortical neurons connected by a glutamatergic synapse.Brain research · 2012Article
- The extended granin family: structure, function, and biomedical implications.Endocrine reviews · 2011Review
- Regulation and distribution of squirrel monkey chorionic gonadotropin and secretogranin II in the pituitary.General and comparative endocrinology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Secretogranin II (SgII) belongs to the granin family of prohormones widely distributed in dense-core secretory granules (DCGs) of endocrine, neuroendocrine, and neuronal cells, including sympathoadrenal chromaffin cells. The mechanisms by which secretory proteins, and granins in particular, are sorted into the regulated secretory pathway are unsettled. We designed a strategy based on novel chimeric forms of human SgII fused to fluorescent (green fluorescent protein) or chemiluminescent (embryonic alkaline phosphatase) reporters to identify trafficking determinants mediating DCG targeting of SgII in sympathoadrenal cells. Three-dimensional deconvolution fluorescence microscopy and secretagogue-stimulated release studies demonstrate that SgII chimeras are correctly targeted to DCGs and released by exocytosis in PC12 and primary chromaffin cells. Results from a Golgi-retained mutant form of SgII suggest that sorting of SgII into DCGs depends on a saturable sorting machinery at the trans-Golgi/trans-Golgi network. Truncation analyses reveal the presence of DCG-targeting signals within both the N- and C-terminal regions of SgII, with the putative alpha-helix-containing SgII-(25-41) and SgII-(334-348) acting as sufficient, independent sorting domains. This study defines sequence features of SgII mediating vesicular targeting in sympathoadrenal cells and suggests a mechanism by which discrete domains of the molecule function in sorting, perhaps by virtue of a particular arrangement in tertiary structure and/or interaction with a specific component of the DCG membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.