Evidence map›Paper›PMID 18299315›Full record

ArticleDiabetes2008

Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients.

Antonio Ceriello, Katherine Esposito, Ludovica Piconi, Michael A Ihnat, Jessica E Thorpe, Roberto Testa, Massimo Boemi, Dario Giugliano

5 registry-linked trialsOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Diabetes, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 643 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
643citing papers in PubMed, 10 pooled it
28.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01524705 phase4completedstarted 2012, after this paper: background citation

FLAT-SUGAR: FLuctuATion Reduction With inSULin and Glp-1 Added togetheR

Ran2012Enrolled102Registered outcomes4Posted comparisons3ConditionsType 2 DiabetesArmsexenatide, Insulin glargine, Metformin, Prandial insulin
PMID 19092145PMID 27208320PMID 11466120PMID 15251625PMID 15326314PMID 15857227PMID 15897298PMID 15939816PMID 12765959PMID 12716809PMID 12711737PMID 11916939other papers from this trial
Open the trial in the graph
NCT02624908 phase4unknown statusstarted 2016, after this paper: background citation

Canagliflozin-Mealtime Insulin Rescue

Ran2016Enrolled40Registered outcomes5Posted comparisons0ConditionsDiabetes Mellitus, Type 2ArmsCanagliflozin, Placebo
PMID 23564919PMID 22699297PMID 22992074PMID 23412078PMID 22686416PMID 22111719PMID 21421802PMID 20649629PMID 18374840PMID 16609094other papers from this trial
Open the trial in the graph
NCT04692415 phase4completednot on this mapstarted 2018, after this paper: background citation

The Differences Between Insulin Glargine U300 and Insulin Degludec U100 in Impact on the Glycaemic Variability, Oxidative Stress, Arterial Stiffness and the Lipid Profiles in Insulin naïve Patients Suffering From Type Two Diabetes Mellitus

TypeinterventionalSponsorUniversity of Split, School of MedicineRan2018 to 2019Enrolled25ConditionsDiabetes Mellitus, Type 2ArmsDegludec, Glargine U300
NCT04730882 completednot on this mapstarted 2021, after this paper: background citation

Effect of Postprandial Hyperglycemia on Vasculature in Type 1 Diabetes and Healthy Adults

TypeobservationalSponsorUniversity of VirginiaRan2021 to 2024Enrolled36ConditionsType 1 Diabetes, Hyperglycemia, PostprandialArmsMixed Meal
NCT05944640 unknown statusnot on this mapstarted 2022, after this paper: background citation

Dynamic Parameters of Glucose Control in Relation to Biomarkers in Serum and Intraocular Fluid in Diabetic Patients With Ocular Complications

TypeobservationalSponsorCharles University, Czech RepublicRan2022 to 2026Enrolled213ConditionsDiabetes ComplicationsArmsIntraocular surgery
3 · Its place in the literature

Who cites it

643 citing papers in PubMed, 10 syntheses or guidelines pooled it, 1,289 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

583 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Antonio CerielloCentre of Excellence in Diabetes and Endocrinology, University Hospital of Coventry and Warwickshire, Warwick Medical School, University of Warwick, Coventry, UK. antonio.ceriello@warwick.ac.uk
Katherine Esposito
Ludovica Piconi
Michael A Ihnat
Jessica E Thorpe
Roberto Testa
Massimo Boemi
Dario Giugliano
University of Naples Federico II · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITIstituto Nazionale di Riposo e Cura per Anziani · ITTranslational Research in Oncology · FRUniversity Hospital Coventry · GBUniversity of Oklahoma Health Sciences Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the possibility that oscillating glucose may outweigh A1C levels in determining the risk for cardiovascular diabetes complications. RESEARCH DESIGN AND

methodsA euinsulinemic hyperglycemic clamp at 5, 10, and 15 mmol/l glucose was given in increasing steps as a single "spike" or oscillating between basal and high levels over 24 h in normal subjects and type 2 diabetic patients. Flow-mediated dilatation, a marker of endothelial function, and plasma 3-nitrotyrosine and 24-h urinary excretion rates of free 8-iso PGF2 alpha, two markers of oxidative stress, were measured over 48 h postclamp.

resultsGlucose at two different levels (10 and 15 mmol/l) resulted in a concentration-dependent fasting blood glucose-independent induction of both endothelial dysfunction and oxidative stress in both normal and type 2 diabetic patients. Oscillating glucose between 5 and 15 mmol/l every 6 h for 24 h resulted in further significant increases in endothelial dysfunction and oxidative stress compared with either continuous 10 or 15 mmol/l glucose.

conclusionsThese data suggest that oscillating glucose can have more deleterious effects than constant high glucose on endothelial function and oxidative stress, two key players in favoring cardiovascular complications in diabetes. Concomitant vitamin C infusion can reverse this impairment.

Indexed as

Oxidative StressBlood GlucoseDiabetes Mellitus, Type 2Endothelium, VascularFemaleGlycated HemoglobinHomeostasisHumansMaleMiddle AgedOscillometryReference ValuesSomatostatinVasodilationBlood GlucoseGlycated HemoglobinSomatostatin

Identifiers

PMID18299315
OpenAlexW2142433177

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.