ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2008
Detection of adamantane-resistant influenza on a microarray.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Amantadine and Rimantadine Inhibit Hepatitis A Virus Replication through the Induction of Autophagy.Journal of virology · 2022Article
- Development and clinical testing of a simple, low-density gel element array for influenza identification, subtyping, and H275Y detection.Journal of virological methods · 2014Article
- Simultaneous detection of oseltamivir- and amantadine-resistant influenza by oligonucleotide microarray visualization.PloS one · 2013Article
- Development of an ELISA-array for simultaneous detection of five encephalitis viruses.Virology journal · 2012Article
- MChip, a low density microarray, differentiates among seasonal human H1N1, North American swine H1N1, and the 2009 pandemic H1N1.Influenza and other respiratory viruses · 2010Article
- Rapid and specific detection of amantadine-resistant influenza A viruses with a Ser31Asn mutation by the cycling probe method.Journal of clinical microbiology · 2010Article
- Applications of microarrays in pathogen detection and biodefence.Trends in biotechnology · 2009Review
- Rapid molecular detection of the H275Y oseltamivir resistance gene mutation in circulating influenza A (H1N1) viruses.Journal of virological methods · 2008Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundInfluenza A has the ability to rapidly mutate and become resistant to the commonly prescribed influenza therapeutics, thereby complicating treatment decisions.
objectiveTo design a cost-effective low-density microarray for use in detection of influenza resistance to the adamantanes. STUDY
designWe have taken advantage of functional genomics and microarray technology to design a DNA microarray that can detect the two most common mutations in the M2 protein associated with adamantane resistance, V27A and S31N.
resultsIn a blind study of 22 influenza isolates, the antiviral resistance-chip (AVR-Chip) had a success rate of 95% for detecting these mutations. Microarray data from a larger set of samples were further analyzed using an artificial neural network and resulted in a correct identification rate of 94% for influenza virus samples that had V27A and S31N mutations.
conclusionsThe AVR-Chip provided a method for rapidly screening influenza viruses for adamantane sensitivity, and the general approach could be easily extended to detect resistance to other chemotherapeutics.
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