ArticleBMC genomics2008
Annotation of expressed sequence tags for the East African cichlid fish Astatotilapia burtoni and evolutionary analyses of cichlid ORFs.
Article in BMC genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 72 citations in OpenAlex.
- The puzzling phylogeography of the haplochromine cichlid fishEcology and evolution · 2018Article
- Parental investment matters for maternal and offspring immune defense in the mouthbrooding cichlid Astatotilapia burtoni.BMC evolutionary biology · 2017Article
- Variations on a theme: Genomics of sex determination in the cichlid fish Astatotilapia burtoni.BMC genomics · 2016Article
- Using an integrative approach to investigate the evolution of behaviour.Evolutionary applications · 2016Review
- Social odors conveying dominance and reproductive information induce rapid physiological and neuromolecular changes in a cichlid fish.BMC genomics · 2015Article
- Gene duplication in an African cichlid adaptive radiation.BMC genomics · 2014Article
- Evolution of genomic structural variation and genomic architecture in the adaptive radiations of African cichlid fishes.Frontiers in genetics · 2014Article
- Tol2-mediated generation of a transgenic haplochromine cichlid, Astatotilapia burtoni.PloS one · 2013Article
- Ancyrocephalidae (Monogenea) of Lake Tanganyika: III: Cichlidogyrus infecting the world's biggest cichlid and the non-endemic tribes Haplochromini, Oreochromini and Tylochromini (Teleostei, Cichlidae).Parasitology research · 2012Article
- Integrating cytogenetics and genomics in comparative evolutionary studies of cichlid fish.BMC genomics · 2012Article
- Genomics of adaptation and speciation in cichlid fishes: recent advances and analyses in African and Neotropical lineages.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Article
- Comparative gene expression profiles for highly similar aggressive phenotypes in male and female cichlid fishes (Julidochromis).The Journal of experimental biology · 2011Article
- Heritability and adaptive significance of the number of egg-dummies in the cichlid fish Astatotilapia burtoni.Proceedings. Biological sciences · 2011Article
- Positive Darwinian selection drives the evolution of the morphology-related gene, EPCAM, in particularly species-rich lineages of African cichlid fishes.Journal of molecular evolution · 2011Article
- Article
- Identification and characterization of gene expression involved in the coloration of cichlid fish using microarray and qRT-PCR approaches.Journal of molecular evolution · 2011Article
- Comparative transcriptomics of Eastern African cichlid fishes shows signs of positive selection and a large contribution of untranslated regions to genetic diversity.Genome biology and evolution · 2011Article
- Comparative physical maps derived from BAC end sequences of tilapia (Oreochromis niloticus).BMC genomics · 2010Article
- An EST resource for tilapia based on 17 normalized libraries and assembly of 116,899 sequence tags.BMC genomics · 2010Article
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Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
Abstract
backgroundThe cichlid fishes in general, and the exceptionally diverse East African haplochromine cichlids in particular, are famous examples of adaptive radiation and explosive speciation. Here we report the collection and annotation of more than 12,000 expressed sequence tags (ESTs) generated from three different cDNA libraries obtained from the East African haplochromine cichlid species Astatotilapia burtoni and Metriaclima zebra.
resultsWe first annotated more than 12,000 newly generated cichlid ESTs using the Gene Ontology classification system. For evolutionary analyses, we combined these ESTs with all available sequence data for haplochromine cichlids, which resulted in a total of more than 45,000 ESTs. The ESTs represent a broad range of molecular functions and biological processes. We compared the haplochromine ESTs to sequence data from those available for other fish model systems such as pufferfish (Takifugu rubripes and Tetraodon nigroviridis), trout, and zebrafish. We characterized genes that show a faster or slower rate of base substitutions in haplochromine cichlids compared to other fish species, as this is indicative of a relaxed or reinforced selection regime. Four of these genes showed the signature of positive selection as revealed by calculating Ka/Ks ratios.
conclusionAbout 22% of the surveyed ESTs were found to have cichlid specific rate differences suggesting that these genes might play a role in lineage specific characteristics of cichlids. We also conclude that the four genes with a Ka/Ks ratio greater than one appear as good candidate genes for further work on the genetic basis of evolutionary success of haplochromine cichlid fishes.
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