ArticleBMC genomics2008
A genome-wide SNP panel for mapping and association studies in the rat.
Article in BMC genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 57 citations in OpenAlex.
- Identification of the 'Haryejosaeng' mandarin cultivar by multiplex PCR-based SNP genotyping.Molecular biology reports · 2020Article
- Genetic Variation in NFKBIE Is Associated With Increased Risk of Pneumococcal Meningitis in Children.EBioMedicine · 2016Article
- A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes.Diabetologia · 2015Article
- The association of beta-2 adrenoceptor genotype with short-cervix mediated preterm birth: a case-control study.BJOG : an international journal of obstetrics and gynaecology · 2015Article
- Genetic variants in the apoptosis gene BCL2L1 improve response to interferon-based treatment of hepatitis C virus genotype 3 infection.International journal of molecular sciences · 2015Article
- Genome-wide association analysis identified SNPs closely linked to a gene resistant to Soil-borne wheat mosaic virus.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2014Article
- Article
- Citrus (Rutaceae) SNP markers based on Competitive Allele-Specific PCR; transferability across the Aurantioideae subfamily.Applications in plant sciences · 2013Article
- Assignment of SNP allelic configuration in polyploids using competitive allele-specific PCR: application to citrus triploid progeny.Annals of botany · 2013Article
- Development of COS-SNP and HRM markers for high-throughput and reliable haplotype-based detection of Lr14a in durum wheat (Triticum durum Desf.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2013Article
- Genome wide SNP discovery in flax through next generation sequencing of reduced representation libraries.BMC genomics · 2012Article
- High-throughput SNP discovery and genotyping for constructing a saturated linkage map of chickpea (Cicer arietinum L.).DNA research : an international journal for rapid publication of reports on genes and genomes · 2012Article
- Article
- SNP marker diversity in common bean (Phaseolus vulgaris L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2011Article
- High-throughput SNP discovery and genotyping in durum wheat (Triticum durum Desf.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2011Article
- A hypomorphic mutation in Lpin1 induces progressively improving neuropathy and lipodystrophy in the rat.The Journal of biological chemistry · 2011Article
- Identification of genetic modifiers of behavioral phenotypes in serotonin transporter knockout rats.BMC genetics · 2010Article
- Genes unlinked to the leptin receptor influence urinary albumin excretion in obese Zucker rats.Physiological genomics · 2010Article
- Preferences of 14 rat strains for 17 taste compounds.Physiology & behavior · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe laboratory rat (Rattus norvegicus) is an important model for human disease, and is extensively used for studying complex traits for example in the physiological and pharmacological fields. To facilitate genetic studies like QTL mapping, genetic makers that can be easily typed, like SNPs, are essential.
resultsA genome-wide set of 820 SNP assays was designed for the KASPar genotyping platform, which uses a technique based on allele specific oligo extension and energy transfer-based detection. SNPs were chosen to be equally spread along all chromosomes except Y and to be polymorphic between Brown Norway and SS or Wistar rat strains based on data from the rat HapMap EU project. This panel was tested on 38 rats of 34 different strains and 3 wild rats to determine the level of polymorphism and to generate a phylogenetic network to show their genetic relationships. As a proof of principle we used this panel to map an obesity trait in Zucker rats and confirmed significant linkage (LOD 122) to chromosome 5: 119-129 Mb, where the leptin receptor gene (Lepr) is located (chr5: 122 Mb).
conclusionWe provide a fast and cost-effective platform for genome-wide SNP typing, which can be used for first-pass genetic mapping and association studies in a wide variety of rat strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.