ArticleJournal of circadian rhythms2008
Structural insights into the function of the core-circadian factor TIMING OF CAB2 EXPRESSION 1 (TOC1).
Article in Journal of circadian rhythms, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Genome-Wide Analysis ofFrontiers in plant science · 2021Article
- Review
- Comparative Analysis of the Chrysanthemum Leaf Transcript Profiling in Response to Salt Stress.PloS one · 2016Article
- The aspartate-less receiver (ALR) domains: distribution, structure and function.PLoS pathogens · 2015Article
- Expression conservation within the circadian clock of a monocot: natural variation at barley Ppd-H1 affects circadian expression of flowering time genes, but not clock orthologs.BMC plant biology · 2012Article
- A reduced-function allele reveals that EARLY FLOWERING3 repressive action on the circadian clock is modulated by phytochrome signals in Arabidopsis.The Plant cell · 2011Article
- Abiotic stress and the plant circadian clock.Plant signaling & behavior · 2011Review
- Rapid assessment of gene function in the circadian clock using artificial microRNA in Arabidopsis mesophyll protoplasts.Plant physiology · 2010Article
- Recent advances in computational modeling as a conduit to understand the plant circadian clock.F1000 biology reports · 2010Article
- Integrating ELF4 into the circadian system through combined structural and functional studies.HFSP journal · 2009Article
- A systematic survey in Arabidopsis thaliana of transcription factors that modulate circadian parameters.BMC genomics · 2008Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe plant circadian clock has at its core a feedback loop that includes TIMING OF CAB2 EXPRESSION 1 (TOC1). This protein has an as of yet unknown biochemical activity. It has been noted that the extreme amino-terminus of this protein is distantly related in sequence to response regulators (RR), and thus TOC1 is a member of the so-called pseudo response regulator (PRR) family. As well, the extreme carboxy-terminus has a small sequence stretch related to the other PRRs and CONSTANS (CO)-like proteins, and this peptide stretch has been termed the CCT (for CONSTANS, CONSTANS-LIKE, TOC1) domain.
methodsTo extend further our understanding of the TOC1 protein, we performed a ROSETTA structural prediction on TOC1 orthologues from four plant species. Phylogenetic interpretations assisted in model construction.
resultsFrom our models, we suggest that TOC1 is a three-domain protein: TOC1 has an amino-terminal signaling-domain related to response receivers, a carboxy-terminal domain that could participate both in metal binding and in transcriptional regulation, and a linker domain that connects the two.
conclusionThe models we present should prove useful in future hypothesis-driven biochemical analyses to test the predictions that TOC1 is a multi-domain signaling component of the plant circadian clock.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.