ArticleBMC psychiatry2008
Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping.
Article in BMC psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Longitudinal epigenome-wide association studies of three male military cohorts reveal multiple CpG sites associated with post-traumatic stress disorder.Clinical epigenetics · 2020Pooled it
- Cross-Talking Pathways of Forkhead Box O1 (FOXO1) Are Involved in the Pathogenesis of Alzheimer's Disease and Huntington's Disease.Oxidative medicine and cellular longevity · 2022Article
- A multi-dimensional characterization of anxiety in monozygotic twin pairs reveals susceptibility loci in humans.Translational psychiatry · 2017Article
- Evidence of a Conserved Molecular Response to Selection for Increased Brain Size in Primates.Genome biology and evolution · 2017Article
- Molecular signatures associated with cognitive deficits in schizophrenia: a study of biopsied olfactory neural epithelium.Translational psychiatry · 2016Article
- Genome-wide methylation profiling of schizophrenia.Balkan journal of medical genetics : BJMG · 2014Article
- Disentangling pooled triad genotypes for association studies.Annals of human genetics · 2014Article
- Genetic variants in transforming growth factor-β gene (TGFB1) affect susceptibility to schizophrenia.Molecular biology reports · 2013Article
- MicroRNA-382 expression is elevated in the olfactory neuroepithelium of schizophrenia patients.Neurobiology of disease · 2013Article
- Extracellular matrix abnormalities in schizophrenia.Neuropharmacology · 2012Review
- Isochromosome 13 in a patient with childhood-onset schizophrenia, ADHD, and motor tic disorder.Molecular cytogenetics · 2012Article
- Associations between DRDs and schizophrenia in a Korean population: multi-stage association analyses.Experimental & molecular medicine · 2011Article
- Extracellular matrix-glial abnormalities in the amygdala and entorhinal cortex of subjects diagnosed with schizophrenia.Archives of general psychiatry · 2010Article
- Validation of pooled genotyping on the Affymetrix 500 k and SNP6.0 genotyping platforms using the polynomial-based probe-specific correction.BMC genetics · 2009Article
- Basic helix-loop-helix transcription factor NEUROG1 and schizophrenia: effects on illness susceptibility, MRI brain morphometry and cognitive abilities.Schizophrenia research · 2008Article
- Molecular profiles of pyramidal neurons in the superior temporal cortex in schizophrenia.Journal of neurogeneticsArticle
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Authors and funding
7 authors.
Funding
Abstract
backgroundSeveral linkage studies suggest that chromosome 5q31-32 might contain risk loci for schizophrenia (SZ). We wanted to identify susceptibility genes for schizophrenia within this region.
methodsWe saturated the interval between markers D5S666 and D5S436 with 90 polymorphic microsatellite markers and genotyped two sets of DNA pools consisting of 300 SZ patients of Bulgarian origin and their 600 parents. Positive associations were followed-up with SNP genotyping.
resultsNominally significant evidence for association (p < 0.05) was found for seven markers (D5S0023i, IL9, RH60252, 5Q3133_33, D5S2017, D5S1481, D5S0711i) which were then individually genotyped in the trios. The predicted associations were confirmed for two of the markers: D5S2017, localised in the SPRY4-FGF1 locus (p = 0.004) and IL9, localized within the IL9 gene (p = 0.014). Fine mapping was performed using single nucleotide polymorphisms (SNPs) around D5S2017 and IL9. In each region four SNPs were chosen and individually genotyped in our full sample of 615 SZ trios. Two SNPs showed significant evidence for association: rs7715300 (p = 0.001) and rs6897690 (p = 0.032). Rs7715300 is localised between the TGFBI and SMAD5 genes and rs6897690 is within the SPRY4 gene.
conclusionOur screening of 5q31-32 implicates three potential candidate genes for SZ: SMAD5, TGFBI and SPRY4.
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