ArticleJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2008
Cellular substrates of action selection: a cluster of higher-order descending neurons shapes body posture and locomotion.
Article in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Variable task switching in the feeding network ofJournal of neurophysiology · 2023Article
- Repetitive nociceptive stimulation elicits complex behavioral changes in Hirudo: evidence of arousal and motivational adaptations.The Journal of experimental biology · 2023Article
- Neural circuit regulation by identified modulatory projection neurons.Frontiers in neuroscience · 2023Review
- The Thermodynamically Expensive Contribution of Three Calcium Sources to Somatic Release of Serotonin.International journal of molecular sciences · 2022Review
- Different microcircuit responses to comparable input from one versus both copies of an identified projection neuron.The Journal of experimental biology · 2020Article
- Whole-central nervous system functional imaging in larval Drosophila.Nature communications · 2015Article
- Serotonin release from the neuronal cell body and its long-lasting effects on the nervous system.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Compensatory plasticity restores locomotion after chronic removal of descending projections.Journal of neurophysiology · 2015Article
- Scanning behavior in the medicinal leech Hirudo verbana.PloS one · 2014Article
- Necessary, sufficient and permissive: a single locomotor command neuron important for intersegmental coordination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Command and compensation in a neuromodulatory decision network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Contextual modulation of behavioral choice.Current opinion in neurobiology · 2011Review
- Keeping it together: mechanisms of intersegmental coordination for a flexible locomotor behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Shared Strategies for Behavioral Switching: Understanding How Locomotor Patterns are Turned on and Off.Frontiers in behavioral neuroscience · 2010Article
- Dopamine activates the motor pattern for crawling in the medicinal leech.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The selection of distinct movements involved in various body postures and locomotion is often dependent on higher-order descending neurons. To study how such cells select different actions, we used a nearly-intact leech preparation (Hirudo sp.) in which cephalic projection interneurons were recorded and stimulated while the leech generated overt behaviors. Two long-distance projecting neurons were identified in the sub-packet of the third neuromere (R3b) of the subesophageal ganglion. These interneurons, named R3b2 and R3b3, produced changes in whole-body posture, crawling and swimming. Cell R3b2 reliably caused the body to become turgid, to hyper-elongate, and to thrash cyclically. Such robust activity resembled struggling behavior exhibited by intact leeches when grasped. The neighboring cell R3b3 elicited body elongation accompanied by a static whole-body bend to the left or right. R3b3 activity was context-dependent, oscillated in phase with crawling, reset the crawl rhythm, and terminated swimming. Both neuronal types responded to multi-modal sensory stimulation delivered to various rostral and caudal regions of the body. Our study illustrates the need to study behavioral selection with a neuroethological approach, and provides a cellular substrate for the motor action-selection cluster proposed for the vertebrate brainstem.
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