ReviewJournal of endocrinological investigation2008
Functioning adrenocortical oncocytoma: the first documented case producing interleukin-6 and review of the literature.
Review in Journal of endocrinological investigation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Giant Adrenal Oncocytoma: A Case Report and Literature Review.IJU case reports · 2026Article
- Prognosis of Adrenal Oncocytic Neoplasms (AONs): Literature Review of 287 Cases and Presentation of the Oldest Patient.Journal of clinical medicine · 2023Review
- Functional plurihormonal adrenal oncocytoma: case report and literature review.Clinical case reports · 2018Article
- [New aspects of tumor pathology of the adrenal glands].Der Pathologe · 2015Review
- Persistent fever and weight loss due to an interleukin-6-producing adrenocortical oncocytoma in a girl--review of the literature.European journal of pediatrics · 2014Review
- Computed tomography and magnetic resonance images of adrenocortical oncocytoma cases.Journal of Korean medical science · 2014Article
- Adrenal tumours are more predominant in females regardless of their histological subtype: a review.World journal of urology · 2013Review
- Bilateral adrenocortical oncocytoma with bilateral myelolipomatous metaplasia.Endocrine pathology · 2012Article
- Oncocytic mania: a review of oncocytic lesions throughout the body.Journal of endocrinological investigation · 2011Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adrenocortical oncocytoma is an extremely rare and predominantly non-functioning tumor. We herein report the first case of an adrenocortical oncocytoma that produces interleukin (IL)-6. A 38-yr-old woman was referred for treatment of a 4-cm adrenal mass. Laboratory test results showed elevated inflammatory parameters. Intriguingly, IL-6 serum level was also high at 30 pg/ml (normal 0-4 pg/ml). The patient underwent laparoscopic right adrenalectomy. Microscopic examination showed that the tumor was an adrenocortical oncocytoma with a unique peripheral lymphoid cuff with germinal centers. Electron microscopy demonstrated that the cytoplasm of the neoplastic cells was packed with numerous abnormal mitochondria. Three observations lead us to consider that this tumor was the primary source of serum IL-6. First, the IL-6 level in blood collected from the right adrenal vein was highest (527 pg/ml) among intra-operative blood samples. Second, neoplastic cells stained positively for IL-6. Third, the serum IL-6 returned to normal levels immediately after surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.