ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2008
Polymorphisms of genes in the lipid metabolism pathway and risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis.Mutation researchPooled it
- Transcriptome Sequencing and Identification ofAnimals : an open access journal from MDPI · 2026Article
- Early detection of gallbladder cancer: Current status and future perspectives.World journal of clinical oncology · 2025Review
- Mendelian randomization study of circulating lipids and biliary tract cancer among East Asians.BMC cancer · 2022Article
- Genetic Regulatory Networks of Apolipoproteins and Associated Medical Risks.Frontiers in cardiovascular medicine · 2021Review
- Upregulation of peroxisome proliferator-activated receptor-α and the lipid metabolism pathway promotes carcinogenesis of ampullary cancer.International journal of medical sciences · 2021Article
- Polymorphisms in PCSK9, LDLR, BCMO1, SLC12A3, and KCNJ1 are Associated with Serum Lipid Profile in Chinese Han Population.International journal of environmental research and public health · 2019Article
- A Rare Missense Mutation and a Polymorphism with High Frequency inAdvanced biomedical research · 2018Article
- Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update.World journal of gastroenterology · 2017Review
- Essential role of polymorphism of Gab1, EGFR, and EGF for the susceptibility of biliary tract cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Variants in motilin, somatostatin and their receptor genes and risk of biliary tract cancers and stones in Shanghai, China.Meta gene · 2014Article
- Molecular characterization of gallbladder cancer using somatic mutation profiling.Human pathology · 2014Article
- Evaluation of the effect of genetic variation on the relationship between statins, cardiovascular disease and cancer.International journal of molecular epidemiology and genetics · 2013Review
- Expression and clinical significance of complement C3, complement C4b1 and apolipoprotein E in pancreatic cancer.Oncology letters · 2013Article
- Novel gene-by-environment interactions: APOB and NPC1L1 variants affect the relationship between dietary and total plasma cholesterol.Journal of lipid research · 2013Article
- Medical risk factors associated with cholangiocarcinoma in Taiwan: a population-based case-control study.PloS one · 2013Article
- A case-control study on the effect of Apolipoprotein E genotypes on gastric cancer risk and progression.BMC cancer · 2012Article
- Concept of the pathogenesis and treatment of cholelithiasis.World journal of hepatology · 2012Article
- Polymorphisms of estrogen receptors and risk of biliary tract cancers and gallstones: a population-based study in Shanghai, China.Carcinogenesis · 2010Article
- Reproductive factors and risks of biliary tract cancers and stones: a population-based study in Shanghai, China.British journal of cancer · 2010Article
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Authors and funding
17 authors at 10 institutions in 3 countries.
Funding
Abstract
Biliary tract cancers, encompassing the gallbladder, extrahepatic bile duct, and ampulla of Vater, are uncommon yet highly fatal malignancies. Gallstones, the primary risk factor for biliary cancers, are linked with hyperlipidemia. We examined the associations of 12 single nucleotide polymorphisms of five genes in the lipid metabolism pathway with the risks of biliary cancers and stones in a population-based case-control study in Shanghai, China. We included 235 gallbladder, 125 extrahepatic bile duct, and 46 ampulla of Vater cancer cases, 880 biliary stone cases, and 779 population controls. Subjects completed an in-person interview and gave blood. Genotyping was conducted by TaqMan assay using DNA from buffy coats. The effects of APOE IVS1+69 (rs440446) and APOB IVS6+360C>T (rs520354) markers were limited to men. Men carrying the G allele of APOE IVS1+69 had a 1.7-fold risk of stones [95% confidence interval (95% CI), 1.2-2.4], a 1.8-fold risk of gallbladder cancer (95% CI, 1.0-3.3), a 3.7-fold risk of bile duct cancer (95% CI, 2.0-7.0), and a 4-fold risk of ampullary cancer (95% CI, 1.4-12.4). Male carriers of the T allele of APOB IVS6+360C>T had a 2-fold risk of bile duct cancer (95% CI, 1.2-3.4). The APOB T-T haplotype (APOB IVS6+360C>T, EX4+56C>T) was associated with a 1.6-fold risk of bile duct cancer (95% CI, 1.1-2.3). Male and female carriers of the T allele of LDLR IVS9-30C>T (rs1003723) had a 1.5-fold risk of bile duct cancer. Our findings suggest that gene variants in the lipid metabolism pathway contribute to the risk of biliary tract stones and cancers, particularly of the bile duct.
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