ArticleBiophysical journal2008
Membrane organization and ionization behavior of the minor but crucial lipid ceramide-1-phosphate.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Investigation of nano- and microdomains formed by ceramide 1 phosphate in lipid bilayers.Scientific reports · 2023Article
- Lateral Segregation of Palmitoyl Ceramide-1-Phosphate in Simple and Complex Bilayers.Biophysical journal · 2019Article
- Magic angle spinningBiochimica et biophysica acta. Biomembranes · 2017Article
- Investigation of the biophysical properties of a fluorescently modified ceramide-1-phosphate.Chemistry and physics of lipids · 2016Article
- Influence of calcium on ceramide-1-phosphate monolayers.Beilstein journal of nanotechnology · 2016Article
- Influence of Hydroxylation, Chain Length, and Chain Unsaturation on Bilayer Properties of Ceramides.Biophysical journal · 2015Article
- Trafficking and Functions of Bioactive Sphingolipids: Lessons from Cells and Model Membranes.Lipid insights · 2015Review
- Development of a Novel Tetravalent Synthetic Peptide That Binds to Phosphatidic Acid.PloS one · 2015Article
- Membrane permeabilization induced by sphingosine: effect of negatively charged lipids.Biophysical journal · 2014Article
- Ceramide 1-phosphate mediates endothelial cell invasion via the annexin a2-p11 heterotetrameric protein complex.The Journal of biological chemistry · 2013Article
- The molecular basis of ceramide-1-phosphate recognition by C2 domains.Journal of lipid research · 2013Article
- The role of ceramide-1-phosphate in biological functions.Handbook of experimental pharmacology · 2013Review
- Emerging methodologies to investigate lipid-protein interactions.Integrative biology : quantitative biosciences from nano to macro · 2012Review
- The physical chemistry of the enigmatic phospholipid diacylglycerol pyrophosphate.Frontiers in plant science · 2012Article
- Sphingomyelinase D activity in model membranes: structural effects of in situ generation of ceramide-1-phosphate.PloS one · 2012Article
- Use of high performance liquid chromatography-electrospray ionization-tandem mass spectrometry for the analysis of ceramide-1-phosphate levels.Journal of lipid research · 2010Article
- Sphingosine-1-phosphate as an amphipathic metabolite: its properties in aqueous and membrane environments.Biophysical journal · 2009Article
- Structure of ceramide-1-phosphate at the air-water solution interface in the absence and presence of Ca2+.Biophysical journal · 2009Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ceramide-1-phosphate (Cer-1-P), one of the simplest of all sphingophospholipids, occurs in minor amounts in biological membranes. Yet recent evidence suggests important roles of this lipid as a novel second messenger with crucial tasks in cell survival and inflammatory responses. We present a detailed description of the physical chemistry of this hitherto little explored membrane lipid. At full hydration Cer-1-P forms a highly organized subgel (crystalline) bilayer phase (L(c)) at low temperature, which transforms into a regular gel phase (L(beta)) at approximately 45 degrees C, with the gel to fluid phase transition (L(beta)-L(alpha)) occurring at approximately 65 degrees C. When incorporated at 5 mol % in a phosphatidylcholine bilayer, the pK(a2) of Cer-1-P, 7.39 +/- 0.03, lies within the physiological pH range. Inclusion of phosphatidylethanolamine in the phosphatidylcholine bilayer, at equimolar ratio, dramatically reduces the pK(a2) to 6.64 +/- 0.03. We explain these results in light of the novel electrostatic/hydrogen bond switch model described recently for phosphatidic acid. In mixtures with dielaidoylphosphatidylethanolamine, small concentrations of Cer-1-P cause a large reduction of the lamellar-to-inverted hexagonal phase transition temperature, suggesting that Cer-1-P induces, like phosphatidic acid, negative membrane curvature in these types of lipid mixtures. These properties place Cer-1-P in a class more akin to certain glycerophospholipids (phosphatidylethanolamine, phosphatidic acid) than to any other sphingolipid. In particular, the similarities and differences between ceramide and Cer-1-P may be relevant in explaining some of their physiological roles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.