ArticleNucleic acids research2008
Solution structure of a let-7 miRNA:lin-41 mRNA complex from C. elegans.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
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- Assembly and analysis of eukaryotic Argonaute-RNA complexes in microRNA-target recognition.Nucleic acids research · 2015Article
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- Tertiary structure-based analysis of microRNA-target interactions.RNA (New York, N.Y.) · 2013Article
- Predicting kissing interactions in microRNA-target complex and assessment of microRNA activity.Nucleic acids research · 2012Article
- A molecular dynamics study of a miRNA:mRNA interaction.Journal of molecular modeling · 2011Article
- miR-107 promotes tumor progression by targeting the let-7 microRNA in mice and humans.The Journal of clinical investigation · 2011Article
- NMR structure of the let-7 miRNA interacting with the site LCS1 of lin-41 mRNA from Caenorhabditis elegans.Nucleic acids research · 2010Article
- Expressing and characterization of mLIN-41 in mouse early embryos and adult muscle tissues.Journal of molecular histology · 2010Article
- Mechanism of microRNA-target interaction: molecular dynamics simulations and thermodynamics analysis.PLoS computational biology · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Let-7 microRNA (miRNA) regulates heterochronic genes in developmental timing of the nematode Caenorhabditis elegans. Binding of miRNA to messenger RNA (mRNA) and structural features of the complex are crucial for gene silencing. We herein present the NMR solution structure of a model mimicking the interaction of let-7 miRNA with its complementary site (LCS 2) in the 3' untranslated region (3'-UTR) of the lin-41 mRNA. A structural study was performed by NMR spectroscopy using NOE restraints, torsion angle restraints and residual dipolar couplings. The 33-nt RNA construct folds into a stem-loop structure that features two stem regions which are separated by an asymmetric internal loop. One of the stems comprises a GU wobble base pair, which does not alter its overall A-form RNA conformation. The asymmetric internal loop adopts a single, well-defined structure in which three uracils form a base triple, while two adenines form a base pair. The 3D structure of the construct gives insight into the structural aspects of interactions between let-7 miRNA and lin-41 mRNA.
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