ArticleNeuroscience2008
The role of transcription factors cyclic-AMP responsive element modulator (CREM) and inducible cyclic-AMP early repressor (ICER) in epileptogenesis.
Article in Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Transcriptional regulatory network during axonal regeneration of dorsal root ganglion neurons: laser-capture microdissection and deep sequencing.Neural regeneration research · 2023Article
- Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility.International journal of molecular sciences · 2023Review
- The Back Muscle Surface Electromyography-Based Fatigue Index: A Digital Biomarker of Human Neuromuscular Aging?Bioengineering (Basel, Switzerland) · 2023Article
- Spatiotemporal Correlation of Epileptiform Activity and Gene ExpressionFrontiers in molecular neuroscience · 2021Article
- Aspects of cAMP Signaling in Epileptogenesis and Seizures and Its Potential as Drug Target.Neurochemical research · 2020Review
- Firing Rate Homeostasis Can Occur in the Absence of Neuronal Activity-Regulated Transcription.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Differential Gene Expression Profile Induced by Valproic Acid (VPA) in Pediatric Epileptic Patients.Genes · 2018Article
- Article
- Epileptogenesis.Cold Spring Harbor perspectives in medicine · 2015Review
- Pathogenesis of epilepsy: challenges in animal models.Iranian journal of basic medical sciences · 2013Review
- Early phase of plasticity-related gene regulation and SRF dependent transcription in the hippocampus.PloS one · 2013Article
- Molecular pathways controlling inhibitory receptor expression.Epilepsia · 2012Review
- Layer-specific CREB target gene induction in human neocortical epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Decreased CREB levels suppress epilepsy.Neurobiology of disease · 2012Article
- Inducible cAMP early repressor (ICER) and brain functions.Molecular neurobiology · 2009Review
- Alteration of epileptogenesis genes.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2009Review
- BDNF selectively regulates GABAA receptor transcription by activation of the JAK/STAT pathway.Science signaling · 2008Article
- Inducible cAMP early repressor acts as a negative regulator for kindling epileptogenesis and long-term fear memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Alterations in the brain that contribute to the development of epilepsy, also called epileptogenesis, are not well understood, which makes it difficult to develop strategies for preventing epilepsy. Here we have studied the role of the CRE binding transcription factors, cyclic-AMP responsive element modulator (CREM) and inducible cyclic-AMP early repressor (ICER), in the development of epilepsy following pilocarpine induced status epilepticus (SE) in mice. Following SE, ICER mRNA and protein are increased in neurons. The increase in ICER, however, is not necessary for neuronal injury following SE as pilocarpine treatment induces equivalent neuronal injury in pyramidal neurons of wild type and CREM/ICER null mice. Following SE, the CREM/ICER null mice develop a more severe epileptic phenotype experiencing approximately threefold more frequent spontaneous seizures. Together these data suggest that the increase in ICER mRNA following SE may have a role in suppressing the severity of epilepsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.