ReviewCurrent opinion in chemical biology2008
An embarrassment of riches: the enzymology of RNA modification.
Review in Current opinion in chemical biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- A cooperative effect of ligands, MgThe Journal of biological chemistry · 2026Article
- Predicting an intrinsic conformational twist in Card1: an in silico study.Journal of molecular modeling · 2026Article
- Key RNA-binding domains in the La protein establish tRNA modification levels in Trypanosoma brucei.Nucleic acids research · 2025Article
- Two riboswitch classes that share a common ligand-binding fold show major differences in the ability to accommodate mutations.Nucleic acids research · 2024Article
- The Biochemical Landscape of Riboswitch Ligands.Biochemistry · 2022Article
- A natural riboswitch scaffold with self-methylation activity.Nature communications · 2021Article
- Synthesis ofBeilstein journal of organic chemistry · 2021Article
- Article
- Naturally occurring modified ribonucleosides.Wiley interdisciplinary reviews. RNA · 2020Review
- Synthetic ligands for PreQNature communications · 2019Article
- Structure and function of preQBiochimica et biophysica acta · 2014Review
- Structural, functional, and taxonomic diversity of three preQ1 riboswitch classes.Chemistry & biology · 2014Article
- Wybutosine biosynthesis: structural and mechanistic overview.RNA biology · 2014Review
- A highly conserved family of domains related to the DNA-glycosylase fold helps predict multiple novel pathways for RNA modifications.RNA biology · 2014Article
- MODOMICS: a database of RNA modification pathways--2013 update.Nucleic acids research · 2013Article
- Functional Analysis of Bacillus subtilis Genes Involved in the Biosynthesis of 4-Thiouridine in tRNA.Journal of bacteriology · 2012Article
- Continuous evolution: protein evolution at warp speed.Nature chemical biology · 2011Article
- Genome annotation and intraviral interactome for the Streptococcus pneumoniae virulent phage Dp-1.Journal of bacteriology · 2011Article
- High-resolution structure of the nitrile reductase QueF combined with molecular simulations provide insight into enzyme mechanism.Journal of molecular biology · 2010Article
- Kissing G domains of MnmE monitored by X-ray crystallography and pulse electron paramagnetic resonance spectroscopy.PLoS biology · 2009Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The maturation of transfer RNA (tRNA) involves extensive chemical modification of the constituent nucleosides and results in the introduction of significant chemical diversity to tRNA. Many of the pathways to these modified nucleosides are characterized by chemically complex transformations, some of which are unprecedented in other areas of biology. To illustrate the scope of the field, recent progress in understanding the enzymology leading to the formation of two distinct classes of modified nucleosides, the thiouridines and queuosine, a 7-deazaguanosine, is reviewed. In particular, recent data validating the involvement of several proposed intermediates in the formation of thiouridines are discussed, including two key enzyme intermediates and the activated tRNA intermediate. The discovery and mechanistic characterization of a new enzyme activity in the queuosine pathway is discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.