ArticleNeuroscience2008
Estrogen and aging affect synaptic distribution of phosphorylated LIM kinase (pLIMK) in CA1 region of female rat hippocampus.
Article in Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 50 citations in OpenAlex.
- Age-dependent sex differences in cofilin1 pathway (LIMK1/SSH1) and its association with AD biomarkers after chronic systemic inflammation in mice.Neurobiology of aging · 2024Article
- Oestradiol as a neuromodulator of learning and memory.Nature reviews. Neuroscience · 2020Review
- Nrg1 Intracellular Signaling Is Neuroprotective upon Stroke.Oxidative medicine and cellular longevity · 2019Article
- Effects of estrogen and aging on synaptic morphology and distribution of phosphorylated Tyr1472 NR2B in the female rat hippocampus.Neurobiology of aging · 2019Article
- Impact of quercetin on tight junctional proteins and BDNF signaling molecules in hippocampus of PCBs-exposed rats.Interdisciplinary toxicology · 2018Article
- Diverse Synaptic Distributions of G Protein-coupled Estrogen Receptor 1 in Monkey Prefrontal Cortex with Aging and Menopause.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Sex in the brain: hormones and sex differences.Dialogues in clinical neuroscience · 2016Review
- G-protein-coupled estrogen receptor 1 is anatomically positioned to modulate synaptic plasticity in the mouse hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Sex differences in stress-related psychiatric disorders: neurobiological perspectives.Frontiers in neuroendocrinology · 2014Review
- Genistein partly eases aging and estropause-induced primary cortical neuronal changes in rats.PloS one · 2014Article
- Reversal of behavioral deficits and synaptic dysfunction in mice overexpressing neuregulin 1.Neuron · 2013Article
- Morphological and molecular changes in aging rat prelimbic prefrontal cortical synapses.Neurobiology of aging · 2013Article
- Insights into rapid modulation of neuroplasticity by brain estrogens.Pharmacological reviews · 2013Review
- Female hippocampal estrogens have a significant correlation with cyclic fluctuation of hippocampal spines.Frontiers in neural circuits · 2013Article
- The ever-changing brain: cellular and molecular mechanisms for the effects of stressful experiences.Developmental neurobiology · 2012Review
- Synaptic distributions of GluA2 and PKMζ in the monkey dentate gyrus and their relationships with aging and memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Role of estrogen receptor alpha and beta expression and signaling on cognitive function during aging.Hippocampus · 2012Review
- The ageing cortical synapse: hallmarks and implications for cognitive decline.Nature reviews. Neuroscience · 2012Review
- Estrogen effects on the brain: actions beyond the hypothalamus via novel mechanisms.Behavioral neuroscience · 2012Review
- Estradiol acts via estrogen receptors alpha and beta on pathways important for synaptic plasticity in the mouse hippocampal formation.Neuroscience · 2012Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
17beta-Estradiol (E) increases axospinous synapse density in the hippocampal CA1 region of young female rats, but not in aged rats. This may be linked to age-related alterations in signaling pathways activated by synaptic estrogen receptor alpha (ER-alpha) that potentially regulate spine formation, such as LIM-kinase (LIMK), an actin depolymerizing factor/cofilin kinase. We hypothesized that, as with ER-alpha, phospho-LIM-kinase (pLIMK) may be less abundant or responsive to E in CA1 synapses of aged female rats. To address this, cellular and subcellular distribution of pLIMK-immunoreactivity (IR) in CA1 was analyzed by light and electron microscopy in young and aged female rats that were ovariectomized and treated with either vehicle or E. pLIMK-IR was found primarily in perikarya within the pyramidal cell layer and dendritic shafts and spines in stratum radiatum (SR). While pLIMK-IR was occasionally present in terminals, post-embedding quantitative analysis of SR showed that pLIMK had a predominant post-synaptic localization and was preferentially localized within the postsynaptic density (PSD). The percentage of pLIMK-labeled synapses increased (30%) with E treatment (P<0.02) in young animals, and decreased (43%) with age (P<0.002) regardless of treatment. The pattern of distribution of pLIMK-IR within dendritic spines and synapses was unaffected by age or E treatment, with the exception of an E-induced increase in the non-synaptic core of spines in young females. These data suggest that age-related synaptic alterations similar to those seen with ER-alpha occur with signaling molecules such as pLIMK, and support the hypothesis that age-related failure of E treatment to increase synapse number in CA1 may be due to changes in the molecular profile of axospinous synapses with respect to signaling pathways linked to formation of additional spines and synapses in response to E.
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Registered trials
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