ReviewMolecular and cellular endocrinology2008
Aspects of endocannabinoid signaling in periimplantation biology.
Review in Molecular and cellular endocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- The Autism-Psychosis Continuum Conundrum: Exploring the Role of the Endocannabinoid System.International journal of environmental research and public health · 2022Pooled it
- Evidence on the effect of in-utero cannabis exposure in neonates.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Metabolic regulation of key developmental events during mammalian embryogenesis.Nature cell biology · 2025Review
- Review
- Nitric oxide positively affects endometrial receptivity via FAAH and NAPE-PLDReproduction & fertility · 2021Article
- Cannabis Use in Pregnant and Breastfeeding Women: Behavioral and Neurobiological Consequences.Frontiers in psychiatry · 2020Review
- Roles of the Hepatic Endocannabinoid and Apelin Systems in the Pathogenesis of Liver Fibrosis.Cells · 2019Review
- Review
- The grass isn't always greener: The effects of cannabis on embryological development.BMC pharmacology & toxicology · 2016Review
- Marijuana, the Endocannabinoid System and the Female Reproductive System.The Yale journal of biology and medicine · 2016Review
- Article
- Endocannabinoids via CB₁ receptors act as neurogenic niche cues during cortical development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Silencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration.The Journal of biological chemistry · 2012Article
- Cannabinoid receptor 1 signaling in embryo neurodevelopment.Birth defects research. Part B, Developmental and reproductive toxicology · 2012Article
- Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells.British journal of pharmacology · 2012Article
- Anandamide induces sperm release from oviductal epithelia through nitric oxide pathway in bovines.PloS one · 2012Article
- Article
- From Fertilisation to Implantation in Mammalian Pregnancy-Modulation of Early Human Reproduction by the Endocannabinoid System.Pharmaceuticals (Basel, Switzerland) · 2010Review
- Histomorphometric evaluation of cannabinoid receptor and anandamide modulating enzyme expression in the human endometrium through the menstrual cycle.Histochemistry and cell biology · 2010Article
- Spatio-temporal expression patterns of anandamide-binding receptors in rat implantation sites: evidence for a role of the endocannabinoid system during the period of placental development.Reproductive biology and endocrinology : RB&E · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Physiological roles of endocannabinoids, a group of endogenously produced cannabinoid-like lipid molecules that activate G protein-coupled cannabinoid receptors, are being increasingly appreciated in female reproduction. Adverse effects of cannabinoids on female fertility have been suspected for decades; however, underlying molecular and genetic bases by which they exert these effects were not clearly understood. The discovery of cannabinoid receptors (CB1 and CB2), endocannabinoid ligands (anandamide and 2-acylglycerol) as well as their key synthetic and hydrolytic pathways has helped to better understand the roles of cannabinoid/endocannabinoid signaling in preimplantation embryo development, oviductal embryo transport, embryo implantation and postimplantation embryonic growth. This review focuses on various aspects of the endocannabinoid system in female fertility based on studies that used knockout mouse models. The information generated from studies in mice is likely to shed deeper insight into fertility regulation in women.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.