ReviewVirus research2008
Murine leukemia virus reverse transcriptase: structural comparison with HIV-1 reverse transcriptase.
Review in Virus research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 64 citations in OpenAlex.
- Structure and mechanism of antiphage retron Eco2.Nature structural & molecular biology · 2026Article
- Expression of thermostable MMLV reverse transcriptase in Escherichia coli by directed mutation.AMB Express · 2024Article
- Engineered CRISPR prime editors with compact, untethered reverse transcriptases.Nature biotechnology · 2023Article
- A flexible split prime editor using truncated reverse transcriptase improves dual-AAV delivery in mouse liver.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- M-MuLV reverse transcriptase: Selected properties and improved mutants.Computational and structural biotechnology journal · 2021Review
- Construction of A Preliminary Three-Dimensional StructureTropical life sciences research · 2020Article
- Intact Viral Particle Counts Measured by Flow Virometry Provide Insight into the Infectivity and Genome Packaging Efficiency of Moloney Murine Leukemia Virus.Journal of virology · 2020Article
- Molecular docking based design of Inhibitors for viral Non-Nucleosidase as potential anti-retroviral agents.Bioinformation · 2020Article
- Current Perspectives of Telomerase Structure and Function in Eukaryotes with Emerging Views on Telomerase in Human Parasites.International journal of molecular sciences · 2018Review
- Pausing kinetics dominates strand-displacement polymerization by reverse transcriptase.Nucleic acids research · 2017Article
- Coordination between the polymerase and RNase H activity of HIV-1 reverse transcriptase.Nucleic acids research · 2017Article
- Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid.Nucleic acids research · 2013Article
- Review
- Crystal structure of xenotropic murine leukaemia virus-related virus (XMRV) ribonuclease H.Bioscience reports · 2012Article
- Intrinsic DNA synthesis fidelity of xenotropic murine leukemia virus-related virus reverse transcriptase.The FEBS journal · 2012Article
- Structural and inhibition studies of the RNase H function of xenotropic murine leukemia virus-related virus reverse transcriptase.Antimicrobial agents and chemotherapy · 2012Article
- Subtype-associated differences in HIV-1 reverse transcription affect the viral replication.Retrovirology · 2010Article
- InTERTpreting telomerase structure and function.Nucleic acids research · 2010Review
- Susceptibility of the human retrovirus XMRV to antiretroviral inhibitors.Retrovirology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Recent X-ray crystal structure determinations of Moloney murine leukemia virus reverse transcriptase (MoMLV RT) have allowed for more accurate structure/function comparisons to HIV-1 RT than were formerly possible. Previous biochemical studies of MoMLV RT in conjunction with knowledge of sequence homologies to HIV-1 RT and overall fold similarities to RTs in general, provided a foundation upon which to build. In addition, numerous crystal structures of the MoMLV RT fingers/palm subdomain had also shed light on one of the critical functions of the enzyme, specifically polymerization. Now in the advent of new structural information, more intricate examination of MoMLV RT in its entirety can be realized, and thus the comparisons with HIV-1 RT may be more critically elucidated. Here, we will review the similarities and differences between MoMLV RT and HIV-1 RT via structural analysis, and propose working models for the MoMLV RT based upon that information.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.