Trial reportAmerican heart journal2008
Outcome in African Americans and other minorities in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).
Trial report in American heart journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Implantable cardiac defibrillators for people with non-ischaemic cardiomyopathy.The Cochrane database of systematic reviews · 2018Pooled it
- Social Determinants of Health-Related Outcomes in an Intervention Following Initial Implantable Cardioverter-Defibrillator Implantation.Journal of the American Heart Association · 2025Trial
- Effectiveness of cardiac resynchronization therapy with defibrillator in at-risk black and white cardiac patients.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2013Trial
- Racial and Ethnic Disparities in Implantable Cardioverter-Defibrillator Utilization: A Contemporary Review.Current treatment options in cardiovascular medicine · 2023Article
- Racial differences in setting of implantable cardioverter-defibrillator placement in older adults with heart failure and association with disparate post-implant outcomes.Frontiers in cardiovascular medicine · 2023Article
- Racial and ethnic differences in implantable cardioverter-defibrillator patient selection, management, and outcomes.Heart rhythm O2 · 2022Review
- Article
- Race, ethnicity, and the risk of sudden death<sup/>.Trends in cardiovascular medicine · 2019Review
- Primary prevention implantable cardioverter-defibrillators in older racial and ethnic minority patients.Circulation. Arrhythmia and electrophysiology · 2015Observational
- Clinical effectiveness of CRT and ICD therapy in heart failure patients by racial/ethnic classification: insights from the IMPROVE HF registry.Journal of the American College of Cardiology · 2014Observational
- Observational
- Obstructive sleep apnea and cardiovascular disease in blacks: a call to action from the Association of Black Cardiologists.American heart journal · 2013Article
- Differential impact of race and risk factors on incidence of atrial fibrillation.American heart journal · 2011Review
- Beat-to-beat three-dimensional ECG variability predicts ventricular arrhythmia in ICD recipients.Heart rhythm · 2010Article
- Antihypertensive therapy in African Americans: findings from an inner-city ambulatory clinic.Journal of clinical hypertension (Greenwich, Conn.) · 2010Article
- Medication adherence is a mediator of the relationship between ethnicity and event-free survival in patients with heart failure.Journal of cardiac failure · 2010Article
- Physicians' knowledge and attitudes regarding implantable cardioverter-defibrillators.Cardiology journal · 2010Article
- Short-term outcomes after hospital discharge in patients admitted with heart failure in Abeokuta, Nigeria: data from the Abeokuta Heart Failure Registry.Cardiovascular journal of AfricaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundThe SCD-HeFT demonstrated that implantable cardioverter/defibrillator (ICD) therapy significantly improved survival compared to medical therapy alone in stable moderately symptomatic heart failure patients with an ejection fraction < or = 35%. The purpose of this report is to describe the outcomes in African Americans (AAs) and other minorities.
methodsOf 2521 patients enrolled, 23% were minorities and 17% were AAs. Baseline demographic, clinical variables, socioeconomic status, and long-term outcomes were compared according to race. Two major prespecified subgroups were examined: heart failure cause (ischemic vs nonischemic) and New York Heart Association class (II vs III).
resultsAt baseline, compared to whites, AAs were younger and had more nonischemic heart failure, lower ejection fractions, worse New York Heart Association functional class, and higher prevalence of a history of nonsustained ventricular tachycardia. Comparable percentages of whites and AAs held paid jobs, but whites had a significantly higher educational level and household income (P = .001). Compliance with ICD implantation and medical therapy was comparable in both subgroups. No significant difference was observed in the rate of ICD discharge among whites and AAs. Adjusted mortality risk was significantly higher in AAs compared to whites (hazard ratio 1.27, P = .038). Mortality was equally reduced in both race groups receiving ICD therapy compared to placebo (hazard ratio 0.65 in AAs and 0.73 in whites).
conclusionsSurvival benefits from ICD therapy in SCD-HeFT were not dependent on race. In addition, in this clinical trial setting, there was no evidence that AAs were less willing to accept ICD therapy than whites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.