ArticleBMC genomics2008
Large-scale analysis of Macaca fascicularis transcripts and inference of genetic divergence between M. fascicularis and M. mulatta.
Article in BMC genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Characterization of the urinary DNA virome of hematopoietic stem cell transplant recipient and healthy cynomolgus macaques.bioRxiv : the preprint server for biology · 2026Article
- DNA methylation and transcriptome analysis reveal epigenomic differences among three macaque species.Evolutionary applications · 2024Article
- Transcriptome analysis and comparison reveal divergence between the Mediterranean and the greenhouse whiteflies.PloS one · 2020Article
- Variable BaselineFrontiers in immunology · 2019Article
- Improved Macaca fascicularis gene annotation reveals evolution of gene expression profiles in multiple tissues.BMC genomics · 2018Article
- The population genomics of rhesus macaques (Macaca mulatta) based on whole-genome sequences.Genome research · 2016Article
- Contrasted patterns of variation and evolutionary convergence at the antiviral OAS1 gene in old world primates.Immunogenetics · 2015Article
- Germline and somatic imprinting in the nonhuman primate highlights species differences in oocyte methylation.Genome research · 2015Article
- A genetic comparison of two alleged subspecies of Philippine cynomolgus macaques.American journal of physical anthropology · 2014Article
- Gene expression profiling of brains from bovine spongiform encephalopathy (BSE)-infected cynomolgus macaques.BMC genomics · 2014Article
- Whole-genome sequencing of tibetan macaque (Macaca Thibetana) provides new insight into the macaque evolutionary history.Molecular biology and evolution · 2014Article
- Transcriptomic analyses reveal the adaptive features and biological differences of guts from two invasive whitefly species.BMC genomics · 2014Article
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- Whole-genome sequencing and analysis of the Malaysian cynomolgus macaque (Macaca fascicularis) genome.Genome biology · 2012Article
- Large-scale transcriptome sequencing and gene analyses in the crab-eating macaque (Macaca fascicularis) for biomedical research.BMC genomics · 2012Article
- Positive selection of Toll-like receptor 2 polymorphisms in two closely related old world monkey species, rhesus and Japanese macaques.Immunogenetics · 2012Article
- Genome-based analysis of the nonhuman primate Macaca fascicularis as a model for drug safety assessment.Genome research · 2011Article
- Transcriptome analysis and comparison reveal divergence between two invasive whitefly cryptic species.BMC genomics · 2011Article
- Molecular evolution of the non-coding eosinophil granule ontogeny transcript.Frontiers in genetics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCynomolgus macaques (Macaca fascicularis) are widely used as experimental animals in biomedical research and are closely related to other laboratory macaques, such as rhesus macaques (M. mulatta). We isolated 85,721 clones and determined 9407 full-insert sequences from cynomolgus monkey brain, testis, and liver. These sequences were annotated based on homology to human genes and stored in a database, QFbase http://genebank.nibio.go.jp/qfbase/.
resultsWe found that 1024 transcripts did not represent any public human cDNA sequence and examined their expression using M. fascicularis oligonucleotide microarrays. Significant expression was detected for 544 (51%) of the unidentified transcripts. Moreover, we identified 226 genes containing exon alterations in the untranslated regions of the macaque transcripts, despite the highly conserved structure of the coding regions. Considering the polymorphism in the common ancestor of cynomolgus and rhesus macaques and the rate of PCR errors, the divergence time between the two species was estimated to be around 0.9 million years ago.
conclusionTranscript data from Old World monkeys provide a means not only to determine the evolutionary difference between human and non-human primates but also to unveil hidden transcripts in the human genome. Increasing the genomic resources and information of macaque monkeys will greatly contribute to the development of evolutionary biology and biomedical sciences.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.