ArticleThe journal of physical chemistry. B2008
Influence of lipid composition on membrane activity of antimicrobial phenylene ethynylene oligomers.
Article in The journal of physical chemistry. B, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Membrane-Targeted Consequences of Acetaminophen Toxicity and Off-Target Effects of Antimicrobial Peptides on Host Cell Membranes.International journal of molecular sciences · 2026Review
- Structural and Functional Effects of the Interaction Between an Antimicrobial Peptide and Its Analogs with Model Bacterial and Erythrocyte Membranes.Biomolecules · 2025Article
- LEGO-lipophosphonoxins: length of hydrophobic module affects permeabilizing activity in target membranes of different phospholipid composition.RSC advances · 2024Article
- Design, synthesis and structure-activity relationship (SAR) studies of an unusual class of non-cationic fatty amine-tripeptide conjugates as novel synthetic antimicrobial agents.Frontiers in pharmacology · 2024Article
- Cholinium-Based Ionic Liquids as Promising Antimicrobial Agents in Pharmaceutical Applications: Surface Activity, Antibacterial Activity and Ecotoxicological Profile.Pharmaceutics · 2023Article
- Facial amphiphilicity index correlating chemical structures with antimicrobial efficacy.Bioactive materials · 2023Article
- Advancements in antimicrobial nanoscale materials and self-assembling systems.Chemical Society reviews · 2022Review
- Model architectures for bacterial membranes.Biophysical reviews · 2022Review
- Article
- A Cell-Free Screen for Bacterial Membrane Disruptors Identifies Mefloquine as a Novel Antibiotic Adjuvant.Antibiotics (Basel, Switzerland) · 2021Article
- Beyond Amphiphilic Balance: Changing Subunit Stereochemistry Alters the Pore-Forming Activity of Nylon-3 Polymers.Journal of the American Chemical Society · 2021Article
- Interactions of Biocidal Polyhexamethylene Guanidine Hydrochloride and Its Analogs with POPC Model Membranes.Polymers · 2017Article
- Calcium and Magnesium Ions Are Membrane-Active against Stationary-Phase Staphylococcus aureus with High Specificity.Scientific reports · 2016Article
- Two interdependent mechanisms of antimicrobial activity allow for efficient killing in nylon-3-based polymeric mimics of innate immunity peptides.Biochimica et biophysica acta · 2014Article
- Designing mimics of membrane active proteins.Accounts of chemical research · 2013Article
- Cationic antimicrobial polymers and their assemblies.International journal of molecular sciences · 2013Review
- Antibacterial drug leads targeting isoprenoid biosynthesis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Nature-inspired antimicrobial polymers--assessment of their potential for biomedical applications.PloS one · 2013Article
- A critical evaluation of random copolymer mimesis of homogeneous antimicrobial peptides.Macromolecules · 2013Article
- Antibacterial mechanism of action of arylamide foldamers.Antimicrobial agents and chemotherapy · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Host defense peptides (HDPs), part of the innate immune system, selectively target the membranes of bacterial cells over that of host cells. As a result, their antimicrobial properties have been under intense study. Their selectivity strongly depends on the chemical and mostly structural properties of the lipids that make up different cell membranes. The ability to synthesize HDP mimics has recently been demonstrated. To better understand how these HDP mimics interact with bilayer membranes, three homologous antimicrobial oligomers (AMOs) 1-3 with an m-phenylene ethynylene backbone and alkyl amine side chains were studied. Among them, AMO 1 is nonactive, AMO 2 is specifically active, and AMO 3 is nonspecifically active against bacteria over human red blood cells, a standard model for mammalian cells. The interactions of these three AMOs with liposomes having different lipid compositions are characterized in detail using a fluorescent dye leakage assay. AMO 2 and AMO 3 caused more leakage than AMO 1 from bacteria membrane mimic liposomes composed of PE/PG lipids. The use of E. coli lipid vesicles gave the same results. Further changes of the lipid compositions revealed that AMO 2 has selectively higher affinity toward PE/PG and E. coli lipids than PC, PC/PG or PC/PS lipids, the major components of mammalian cell membranes. In contrast, AMO 3 is devoid of this lipid selectivity and interacts with all liposomes with equal ease; AMO 1 remains inactive. These observations suggest that lipid type and structure are more important in determining membrane selectivity than lipid headgroup charges for this series of HDP mimics.
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