ArticleThe Journal of clinical investigation2008
Growth hormone resurrects adult human thymus during HIV-1 infection.
Article in The Journal of clinical investigation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00071240 (The Use of Recombinant Growth Hormone to Enhance T-Cell Production in Adults Infected With HIV-1), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Use of Recombinant Growth Hormone to Enhance T-Cell Production in Adults Infected With HIV-1
Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Cytoskeleton proteins, the structural basis of T-lymphocyte and TEC restructure during rapid thymus regeneration.Histology and histopathology · 2025Review
- Immune tolerance and the prevention of autoimmune diseases essentially depend on thymic tissue homeostasis.Frontiers in immunology · 2024Review
- Infection-Associated Thymic Atrophy.Frontiers in immunology · 2021Review
- Thymus Degeneration and Regeneration.Frontiers in immunology · 2021Review
- Article
- Hormonal control of T-cell development in health and disease.Nature reviews. Endocrinology · 2016Review
- The growth hormone receptor: mechanism of activation and clinical implications.Nature reviews. Endocrinology · 2010Review
- Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways.Current opinion in pharmacology · 2010Review
- Rational design of HIV vaccine and microbicides: report of the EUROPRISE annual conference.Journal of translational medicine · 2010Article
- 21st century endocrinology.Clinical medicine (London, England) · 2009Review
- Effects of recombinant human growth hormone on HIV-1-specific T-cell responses, thymic output and proviral DNA in patients on HAART: 48-week follow-up.Journal of immune based therapies and vaccines · 2008Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In conditions of severe T cell depletion, such as HIV-1 infection, limited T cell production by the thymus can thwart the immune response, putting individuals at increased risk of infection with opportunistic pathogens. In this issue of the JCI, Napolitano et al. report, in a prospective, randomized study, that treatment of HIV-1-infected adults with growth hormone may reverse thymic atrophy, as reflected by increased de novo thymic T cell production accompanied by increased peripheral T cell production (see the related article beginning on page 1085). While the long-term immunological and clinical benefits of growth hormone treatment remain unclear, the data suggest a way in which to enhance thymopoiesis and peripheral T cell production in immunodeficient individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.