ArticleJournal of immunology (Baltimore, Md. : 1950)2008
Proliferative expansion and acquisition of effector activity by memory CD4+ T cells in the lungs following pulmonary virus infection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Mapping Genetic Susceptibility to Stenosis in the Proximal Airway.The Laryngoscope · 2023Article
- Gut Dysbiosis Thwarts the Efficacy of Vaccine AgainstFrontiers in immunology · 2020Article
- Virus-induced asthma attack: The importance of allergic inflammation in response to viral antigen in an animal model of asthma.PloS one · 2017Article
- Mucosal resident memory CD4 T cells in protection and immunopathology.Frontiers in immunology · 2014Review
- Paramyxovirus infection regulates T cell responses by BDCA-1+ and BDCA-3+ myeloid dendritic cells.PloS one · 2014Article
- Immune suppression by neutrophils and granulocytic myeloid-derived suppressor cells: similarities and differences.Cellular and molecular life sciences : CMLS · 2013Review
- Article
- Cutting edge: contribution of lung-resident T cell proliferation to the overall magnitude of the antigen-specific CD8 T cell response in the lungs following murine influenza virus infection.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- CXCR3 directs antigen-specific effector CD4+ T cell migration to the lung during parainfluenza virus infection.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Pulmonary eosinophilia is attenuated by early responding CD8(+) memory T cells in a murine model of RSV vaccine-enhanced disease.Viral immunology · 2009Article
- Characterization of respiratory syncytial virus M- and M2-specific CD4 T cells in a murine model.Journal of virology · 2009Article
- The host response and molecular pathogenesis associated with respiratory syncytial virus infection.Future microbiology · 2009Review
- Fas ligand is required for the development of respiratory syncytial virus vaccine-enhanced disease.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The memory CD4+ T cell response to the respiratory syncytial virus (RSV) attachment (G) protein in the lungs of primed BALB/c mice undergoing challenge pulmonary RSV infection is dominated by effector T cells expressing a single Vbeta-chain, Vbeta14. We have used Vbeta14 expression to examine the kinetics of the activation, accumulation, and acquisition of the effector activity of memory CD4+ T cells responding to pulmonary infection. This analysis revealed that proliferative expansion and effector CD4+ T cell differentiation preferentially occur in the respiratory tract following rapid activation within and egress from the lymph nodes draining the respiratory tract. These findings suggest that, in response to natural infection at a peripheral mucosal site such as the lungs, memory CD4+ T cell expansion and differentiation into activated effector T cells may occur predominantly in the peripheral site of infection rather than exclusively in the lymph nodes draining the site of infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.