ReviewMolecular endocrinology (Baltimore, Md.)2008
Nuclear receptor location analyses in mammalian genomes: from gene regulation to regulatory networks.
Review in Molecular endocrinology (Baltimore, Md.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Review
- Article
- Orphan Nuclear Receptor ERRγ Is a Novel Transcriptional Regulator of IL-6 Mediated Hepatic BMP6 Gene Expression in Mice.International journal of molecular sciences · 2020Article
- ERRα as a Bridge Between Transcription and Function: Role in Liver Metabolism and Disease.Frontiers in endocrinology · 2019Review
- Key regulator of cellular metabolism, estrogen-related receptor α, a new therapeutic target in endocrine-related gynecological tumor.Cancer management and research · 2018Review
- What's new in estrogen receptor action in the female reproductive tract.Journal of molecular endocrinology · 2016Review
- Feed-forward transcriptional programming by nuclear receptors: regulatory principles and therapeutic implications.Pharmacology & therapeutics · 2015Review
- Integrative analysis of SF-1 transcription factor dosage impact on genome-wide binding and gene expression regulation.Nucleic acids research · 2013Article
- Article
- Progesterone synthesis in the nervous system: implications for myelination and myelin repair.Frontiers in neuroscience · 2012Article
- The estrogen receptor α colocalizes with proopiomelanocortin in hypothalamic neurons and binds to a conserved motif present in the neuron-specific enhancer nPE2.European journal of pharmacology · 2011Article
- A modulated empirical Bayes model for identifying topological and temporal estrogen receptor α regulatory networks in breast cancer.BMC systems biology · 2011Article
- Global analysis of the impact of environmental perturbation on cis-regulation of gene expression.PLoS genetics · 2011Article
- FOXA1 is a key determinant of estrogen receptor function and endocrine response.Nature genetics · 2011Article
- Genome-wide analysis of glucocorticoid receptor binding regions in adipocytes reveal gene network involved in triglyceride homeostasis.PloS one · 2010Article
- The rules of DNA recognition by the androgen receptor.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Genome-wide analysis of binding sites and direct target genes of the orphan nuclear receptor NR2F1/COUP-TFI.PloS one · 2010Article
- HRTBLDb: an informative data resource for hormone receptors target binding loci.Nucleic acids research · 2010Article
- Physiological genomics identifies estrogen-related receptor alpha as a regulator of renal sodium and potassium homeostasis and the renin-angiotensin pathway.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) but not PPARalpha serves as a plasma free fatty acid sensor in liver.Molecular and cellular biology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid progress in mapping nuclear receptor binding sites, referred to as "location analysis," has recently been achieved through the use of chromatin immunoprecipitation approaches. Location analysis can be performed on a single locus or cover a complete genome, and the resulting datasets can be probed to identify direct target genes and/or investigate the molecular mechanisms by which nuclear receptors control gene expression. In addition, when coupled with other genetic and functional genomics investigative methods, location analysis has proven to be a powerful tool with which to identify novel biological functions of nuclear receptors and build transcriptional regulatory networks. Thus, the knowledge gained from several recent chromatin immunoprecipitation-based studies has challenged basic concepts of nuclear receptor action, offered new insights into gene-regulatory mechanisms, and led to the identification of nuclear receptor-controlled biological functions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.