ArticleThe American journal of pathology2008
Lymphadenopathy in a novel mouse model of Bartonella-induced cat scratch disease results from lymphocyte immigration and proliferation and is regulated by interferon-alpha/beta.
Article in The American journal of pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Uncovering the truth about cat-scratch disease.Open veterinary journal · 2025Review
- Evaluation of the available animal models forOne health (Amsterdam, Netherlands) · 2024Review
- IsLeukemia research reports · 2024Review
- Article
- Chikungunya virus impairs draining lymph node function by inhibiting HEV-mediated lymphocyte recruitment.JCI insight · 2018Article
- Type I Interferon Signaling Is Required for CpG-Oligodesoxynucleotide-Induced Control ofFrontiers in immunology · 2018Article
- Bartonella henselae is usually not viable in lymph nodes of patients with cat scratch disease.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Article
- Bartonella infection in rodents and their flea ectoparasites: an overview.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2015Review
- Zebrafish embryo model of Bartonella henselae infection.Zebrafish · 2014Article
- Hypertrophy of infected Peyer's patches arises from global, interferon-receptor, and CD69-independent shutdown of lymphocyte egress.Mucosal immunology · 2014Article
- Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell Types.Frontiers in immunology · 2014Review
- Bartonella and Brucella--weapons and strategies for stealth attack.Cold Spring Harbor perspectives in medicine · 2013Article
- Spectrum of radiological manifestations of paediatric cat-scratch disease.Pediatric radiology · 2012Article
- Intruders below the radar: molecular pathogenesis of Bartonella spp.Clinical microbiology reviews · 2012Review
- Bartonella henselae in skin biopsy specimens of patients with cat-scratch disease.Emerging infectious diseases · 2010Article
- Impairment of circulating endothelial progenitors in Down syndrome.BMC medical genomics · 2010Article
- Human isolates of Bartonella tamiae induce pathology in experimentally inoculated immunocompetent mice.BMC infectious diseases · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In immunocompetent humans, cat scratch disease (CSD) is elicited by the Gram-negative bacterium Bartonella henselae and is characterized by a benign regional lymphadenopathy, the pathogenesis of which is poorly understood. Here, we describe a novel mouse model of Bartonella-induced CSD-like disease that allowed us to investigate the mechanisms leading to lymphadenopathy in vivo. In wild-type mice, a subcutaneous inoculation of either viable or inactivated B. henselae led to a strong swelling of the draining lymph node, which was long-lasting despite the rapid elimination of the bacteria. Carboxyfluorescein- and bromodesoxyuridine-labeling experiments showed that lymph node enlargement resulted from modified immigration and enhanced proliferation of lymphocytes, preferentially of B cells. A comparative analysis of B. henselae and the rodent pathogen B. grahamii in wild-type versus interferon-alpha/beta-receptor I chain-deficient mice revealed that interferon-alpha/beta is not only differentially induced by these two Bartonella species but also exerts an inhibitory effect on the development of lymphadenopathy both in vitro and in vivo. These data demonstrate that the lymphadenopathy of human CSD can be reproduced and studied in a mouse model and provide the first insights into the underlying immunological mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.