ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2008
Uncoupling protein-2 modulates the lipid metabolic response to fasting in mice.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- UCP2 as a Cancer Target through Energy Metabolism and Oxidative Stress Control.International journal of molecular sciences · 2022Review
- Activation of UCP2 by anethole trithione suppresses neuroinflammation after intracerebral hemorrhage.Acta pharmacologica Sinica · 2022Article
- Circadian Regulation of the Pancreatic Beta Cell.Endocrinology · 2021Review
- The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepatic Metabolism.International journal of molecular sciences · 2021Article
- Review
- UCP2-induced hypoxia promotes lipid accumulation and tubulointerstitial fibrosis during ischemic kidney injury.Cell death & disease · 2020Article
- Role of ketone signaling in the hepatic response to fasting.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Pterostilbene Reduces Liver Steatosis and Modifies Hepatic Fatty Acid Profile in Obese Rats.Nutrients · 2019Article
- Lack of Additive Effects of Resveratrol and Energy Restriction in the Treatment of Hepatic Steatosis in Rats.Nutrients · 2017Article
- Uncoupling protein 2 regulates daily rhythms of insulin secretion capacity in MIN6 cells and isolated islets from male mice.Molecular metabolism · 2017Article
- Hepatic adaptations to maintain metabolic homeostasis in response to fasting and refeeding in mice.Nutrition & metabolism · 2016Article
- UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis.The Journal of clinical investigation · 2015Article
- Mitochondrial uncoupling and the reprograming of intermediary metabolism in leukemia cells.Frontiers in oncology · 2013Article
- Uncoupling protein 2 gene polymorphisms are associated with obesity.Cardiovascular diabetology · 2012Article
- TRPV1 activation prevents nonalcoholic fatty liver through UCP2 upregulation in mice.Pflugers Archiv : European journal of physiology · 2012Article
- Article
- Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- The Ribosomal Protein-Mdm2-p53 Pathway and Energy Metabolism: Bridging the Gap between Feast and Famine.Genes & cancer · 2011Article
- Uncoupling protein-2 decreases the lipogenic actions of ghrelin.Endocrinology · 2010Article
- Uncoupling protein-2 regulates lifespan in mice.American journal of physiology. Endocrinology and metabolism · 2009Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Uncoupling protein-2 (UCP2) regulates insulin secretion by controlling ATP levels in beta-cells. Although UCP2 deficiency improves glycemic control in mice, increased expression of UCP2 interferes with glucose-stimulated insulin secretion. These observations link UCP2 to beta-cell dysfunction in type 2 diabetes with a perplexing evolutionary role. We found higher residual serum insulin levels and blunted lipid metabolic responses in fasted ucp2(-/-) mice, supporting the concept that UCP2 evolved to suppress insulin effects and to accommodate the fuel switch to fatty acids during starvation. In the absence of UCP2, fasting initially promotes peripheral lipolysis and hepatic fat accumulation at less than expected rates but culminates in protracted steatosis, indicating diminished hepatic utilization and clearance of fatty acids. We conclude that UCP2-mediated control of insulin secretion is a physiologically relevant mechanism of the metabolic response to fasting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.