ArticleThe Journal of physiology2008
Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic-pituitary-adrenal function.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 136 citations in OpenAlex.
- Insights from animal models: Dissecting the independent roles of oxygen and nutrients in the fetal origins of cardiovascular disease.The Journal of physiology · 2026Review
- The Role of Feed Restriction on DNA Methylation, Feed Efficiency, Metabolome, Biochemical Profile, and Progesterone Patterns in the Female Filial Generation (F1) Obtained From Early Feed Restricted Ewes (F0).Frontiers in physiology · 2021Article
- Article
- Strength of nonhuman primate studies of developmental programming: review of sample sizes, challenges, and steps for future work.Journal of developmental origins of health and disease · 2020Review
- Ancestral stress programs sex-specific biological aging trajectories and non-communicable disease risk.Aging · 2020Article
- Developmental origin and sex-specific risk for infections and immune diseases later in life.Seminars in immunopathology · 2019Review
- Maternal Protein Restriction in Two Successive Generations Impairs Mitochondrial Electron Coupling in the Progeny's Brainstem ofFrontiers in neuroscience · 2019Article
- Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic.The Journal of physiology · 2018Article
- Dietary fatty acids sex-specifically modulate guinea pig postnatal development via cortisol concentrations.Scientific reports · 2018Article
- Primary Pediatric Hypertension: Current Understanding and Emerging Concepts.Current hypertension reports · 2017Review
- Grandmaternal stress during pregnancy and DNA methylation of the third generation: an epigenome-wide association study.Translational psychiatry · 2017Article
- The placental gateway of maternal transgenerational epigenetic inheritance.Journal of genetics · 2017Review
- Impacts of prenatal nutrition on animal production and performance: a focus on growth and metabolic and endocrine function in sheep.Journal of animal science and biotechnology · 2017Review
- The transgenerational inheritance of autism-like phenotypes in mice exposed to valproic acid during pregnancy.Scientific reports · 2016Article
- Prenatal stress programs neuroendocrine stress responses and affective behaviors in second generation rats in a sex-dependent manner.Psychoneuroendocrinology · 2015Article
- Maternal protein restriction increases respiratory and sympathetic activities and sensitizes peripheral chemoreflex in male rat offspring.The Journal of nutrition · 2015Article
- Intrauterine programming.Iranian journal of basic medical sciences · 2015Review
- Mechanisms of non-genetic inheritance and psychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Review
- Article
- Developmental programming of hypothalamic neuronal circuits: impact on energy balance control.Frontiers in neuroscience · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
The perinatal environment is a powerful determinant of risk for developing disease in later life. Here, we have shown that maternal undernutrition causes dramatic changes in heart structure and hypothalamo-pituitary-adrenal (HPA) function across two generations. Pregnant guinea pigs were fed 70% of normal intake from gestational days 1-35 (early restriction; ER), or 36-70 (late restriction; LR). Female offspring (F(1)) were mated and fed ad libitum to create second generation (F(2)) offspring. Heart morphology, blood pressure, baroreceptor and HPA function were assessed in male F(1) and F(2) offspring. ER(F1) males exhibited elevated blood pressure, increased left ventricular (LV) wall thickness and LV mass. These LV effects were maintained in the ER(F2) offspring. Maternal undernutrition increased basal cortisol and altered HPA responsiveness to challenge in both generations; effects were greatest in LR groups. In conclusion, moderate maternal undernutrition profoundly modifies heart structure and HPA function in adult male offspring for two generations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.