ReviewSleep medicine reviews2008
Narcolepsy: immunological aspects.
Review in Sleep medicine reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 90 citations in OpenAlex.
- Cytokines in narcolepsy type 1: pathogenic relevance, biomarker potential, and future directions.Frontiers in neurology · 2026Review
- Molecular mechanism of tumour necrosis factor alpha regulates hypocretin (orexin) expression, sleep and behaviour.Journal of cellular and molecular medicine · 2019Article
- Narcolepsy and adjuvanted pandemic influenza A (H1N1) 2009 vaccines - Multi-country assessment.Vaccine · 2018Article
- A practical approach to the diagnosis and management of sleep disorders in patients with multiple sclerosis.Therapeutic advances in neurological disorders · 2015Review
- The complementary roles of Phase 3 trials and post-licensure surveillance in the evaluation of new vaccines.Vaccine · 2015Review
- History of narcolepsy at Stanford University.Immunologic research · 2014Review
- The autoimmune basis of narcolepsy.Current opinion in neurobiology · 2013Review
- AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland.PloS one · 2012Article
- Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland.PloS one · 2012Article
- Genetics of sleep and sleep disorders.Cell · 2011Review
- Furthering the understanding of the pathophysiology of narcolepsy.Current neurology and neuroscience reports · 2011Article
- Tumor necrosis factor-alpha regulates the Hypocretin system via mRNA degradation and ubiquitination.Biochimica et biophysica acta · 2011Article
- Article
- Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy.Sleep · 2010Article
- Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients.The Journal of clinical investigation · 2010Article
- Article
- Animal models of narcolepsy.CNS & neurological disorders drug targets · 2009Article
- The economic consequences of narcolepsy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2009Article
- Narcolepsy is strongly associated with the T-cell receptor alpha locus.Nature genetics · 2009Article
- An autoantibody in narcolepsy disrupts colonic migrating motor complexes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Narcolepsy with cataplexy is a debilitating sleep disorder with an estimated prevalence of about 0.05%. Narcolepsy is caused by a selective loss of hypocretin (orexin) producing neurons in the perifornical hypothalamus. Based on the very strong association with the HLA subtype DQB1*0602, it is currently hypothesized narcolepsy is caused by an autoimmune-mediated process directed at the hypocretin neurons. So far however, studies focusing on general markers of (auto)immune activation, as well as humoral immunity against the hypocretin system have not yielded consistent results supporting this hypothesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.