ReviewSurgery2008
Bile and pancreatic juice exclusion activates acinar stress kinases and exacerbates gallstone pancreatitis.
Review in Surgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Research Progress onMediators of inflammation · 2026Review
- Severe acute gallstone pancreatitis with diffuse hemorrhagic gastritis.Journal of surgical case reports · 2018Article
- Biliary pancreatitis. Deadly threat to the elderly. Is it a real threat?International journal of health sciences · 2015Article
- Systemic inflammation with multiorgan dysfunction is the cause of death in murine ligation-induced acute pancreatitis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2011Article
- Etiology and diagnosis of acute biliary pancreatitis.Nature reviews. Gastroenterology & hepatology · 2010Review
- Dominant negative p38 mitogen-activated protein kinase expression inhibits NF-kappaB activation in AR42J cells.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2010Article
- Acute pancreatitis: etiology and common pathogenesis.World journal of gastroenterology · 2009Review
- Experimental obstructive cholestasis: the wound-like inflammatory liver response.Fibrogenesis & tissue repair · 2008Article
- Murine pancreatic duct ligation induces stress kinase activation, acute pancreatitis, and acute lung injury.American journal of surgery · 2008Article
- Enteral exclusion increases MAP kinase activation and cytokine production in a model of gallstone pancreatitis.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
hypothesisBile and pancreatic juice exclusion from gut activates acinar stress kinases and exacerbates gallstone pancreatitis as evidenced by the ameliorating effects of replacement therapy in an experimental model of duct ligation-induced acute pancreatitis. In the early stages of gallstone pancreatitis, bile-pancreatic juice cannot enter the gut. Enteral exclusion worsens pancreatitis by causing feedback hyperstimulation of the exocrine pancreas that activates acinar cell stress kinases. Investigations using a unique surgical model, the Donor Rat Model, showed that duodenal replacement of bile-pancreatic juice in rats with duct ligation attenuates pancreatic stress kinase activation, reduces pancreatic cytokine production, and ameliorates pancreatic morphologic changes. These findings suggest that exclusion-induced acinar hyperstimulation, in the presence of duct obstruction, exacerbates acute pancreatitis via stress kinase activation. Although acinar hyperstimulation has often been implicated in the pathogenesis of acute pancreatitis, the lack of supporting evidence remains a conspicuous void. The proposed hypothesis draws on fresh evidence to present a new paradigm that reexamines the role of exocrine pancreatic hyperstimulation in gallstone pancreatitis pathogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.