ArticleGenome biology2008
Systems biology meets stress ecology: linking molecular and organismal stress responses in Daphnia magna.
Article in Genome biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 167 citations in OpenAlex.
- Interactive Effects of Copper Contamination and Salinization Across Multiple Genotypes ofEcology and evolution · 2025Article
- Article
- Greater toxic potency of bisphenol AF than bisphenol A in growth, reproduction, and transcription of genes in Daphnia magna.Environmental science and pollution research international · 2021Article
- De Novo Transcriptome Assembly and Gene Expression Profiling of the CopepodMarine drugs · 2020Article
- Ecotoxicity of malathion pesticide and its genotoxic effects over the biomarker comet assay in Daphnia magna.Environmental monitoring and assessment · 2020Article
- Transcriptome sequencing of a keystone aquatic herbivore yields insights on the temperature-dependent metabolism of essential lipids.BMC genomics · 2019Article
- Tryptophan hydroxylase (TRH) loss of function mutations in Daphnia deregulated growth, energetic, serotoninergic and arachidonic acid metabolic signalling pathways.Scientific reports · 2019Article
- Developmental and reproductive effects of tamoxifen on Daphnia magna.Environmental monitoring and assessment · 2018Article
- Tryptophan hydroxylase (TRH) loss of function mutations induce growth and behavioral defects in Daphnia magna.Scientific reports · 2018Article
- Transcriptional changes measured in rice roots after exposure to arsenite-contaminated sediments.Environmental science and pollution research international · 2018Article
- Bi-directional effects of vitamin BScientific reports · 2017Article
- Regulation of gene expression is associated with tolerance of the Arctic copepodEcology and evolution · 2017Article
- Conserved Transcription Factors Steer Growth-Related Genomic Programs in Daphnia.Genome biology and evolution · 2017Article
- De novo assembly of a tadpole shrimp (Triops newberryi) transcriptome and preliminary differential gene expression analysis.Molecular ecology resources · 2017Article
- Do microplastic particles affect Daphnia magna at the morphological, life history and molecular level?PloS one · 2017Article
- Chronic exposures to low and high concentrations of ibuprofen elicit different gene response patterns in a euryhaline fish.Environmental science and pollution research international · 2015Article
- Ecotoxicogenomic approaches for understanding molecular mechanisms of environmental chemical toxicity using aquatic invertebrate, Daphnia model organism.International journal of molecular sciences · 2015Review
- Arachidonic acid enhances reproduction in Daphnia magna and mitigates changes in sex ratios induced by pyriproxyfen.Environmental toxicology and chemistry · 2015Article
- Article
- Genome-wide transcription profiles reveal genotype-dependent responses of biological pathways and gene-families in Daphnia exposed to single and mixed stressors.Environmental science & technology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIbuprofen and other nonsteroidal anti-inflammatory drugs have been designed to interrupt eicosanoid metabolism in mammals, but little is known of how they affect nontarget organisms. Here we report a systems biology study that simultaneously describes the transcriptomic and phenotypic stress responses of the model crustacean Daphnia magna after exposure to ibuprofen.
resultsOur findings reveal intriguing similarities in the mode of action of ibuprofen between vertebrates and invertebrates, and they suggest that ibuprofen has a targeted impact on reproduction at the molecular, organismal, and population level in daphnids. Microarray expression and temporal real-time quantitative PCR profiles of key genes suggest early ibuprofen interruption of crustacean eicosanoid metabolism, which appears to disrupt signal transduction affecting juvenile hormone metabolism and oogenesis.
conclusionCombining molecular and organismal stress responses provides a guide to possible chronic consequences of environmental stress for population health. This could improve current environmental risk assessment by providing an early indication of the need for higher tier testing. Our study demonstrates the advantages of a systems approach to stress ecology, in which Daphnia will probably play a major role.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.