ArticleGenome biology2008
Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia.
Article in Genome biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Genetic susceptibility ofGlobal medical genetics · 2025Article
- Complete miRNA-15/16 loss in mice promotes hematopoietic progenitor expansion and a myeloid-biased hyperproliferative state.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Integrated decoding hematopoiesis and leukemogenesis using single-cell sequencing and its medical implication.Cell discovery · 2021Article
- Molecular networks in Network Medicine: Development and applications.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- The Role of ARID5B in Acute Lymphoblastic Leukemia and Beyond.Frontiers in genetics · 2020Review
- Genetic susceptibility in childhood acute lymphoblastic leukemia.Medical oncology (Northwood, London, England) · 2017Review
- Replication analysis confirms the association of several variants with acute myeloid leukemia in Chinese population.Journal of cancer research and clinical oncology · 2016Article
- ARID5B polymorphism confers an increased risk to acquire specific MLL rearrangements in early childhood leukemia.BMC cancer · 2014Article
- Intron 3 of the ARID5B gene: a hot spot for acute lymphoblastic leukemia susceptibility.Journal of cancer research and clinical oncology · 2013Article
- An integrated approach to characterize transcription factor and microRNA regulatory networks involved in Schwann cell response to peripheral nerve injury.BMC genomics · 2013Article
- Article
- Current evidence for an inherited genetic basis of childhood acute lymphoblastic leukemia.International journal of hematology · 2013Review
- A motif-independent metric for DNA sequence specificity.BMC bioinformatics · 2011Article
- Physical Module Networks: an integrative approach for reconstructing transcription regulation.Bioinformatics (Oxford, England) · 2011Article
- Genomic profiling of high-risk acute lymphoblastic leukemia.Leukemia · 2010Review
- Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia.Nature genetics · 2009Article
- Germline genomic variants associated with childhood acute lymphoblastic leukemia.Nature genetics · 2009Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAcute myeloid leukemia (AML) comprises a group of diseases characterized by the abnormal development of malignant myeloid cells. Recent studies have demonstrated an important role for aberrant transcriptional regulation in AML pathophysiology. Although several transcription factors (TFs) involved in myeloid development and leukemia have been studied extensively and independently, how these TFs coordinate with others and how their dysregulation perturbs the genetic circuitry underlying myeloid differentiation is not yet known. We propose an integrated approach for mammalian genetic network construction by combining the analysis of gene expression profiling data and the identification of TF binding sites.
resultsWe utilized our approach to construct the genetic circuitries operating in normal myeloid differentiation versus acute promyelocytic leukemia (APL), a subtype of AML. In the normal and disease networks, we found that multiple transcriptional regulatory cascades converge on the TFs Rora and Rxra, respectively. Furthermore, the TFs dysregulated in APL participate in a common regulatory pathway and may perturb the normal network through Fos. Finally, a model of APL pathogenesis is proposed in which the chimeric TF PML-RARalpha activates the dysregulation in APL through six mediator TFs.
conclusionThis report demonstrates the utility of our approach to construct mammalian genetic networks, and to obtain new insights regarding regulatory circuitries operating in complex diseases in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.