ArticleLiver international : official journal of the International Association for the Study of the Liver2008
Physiological variations of stem cell factor and stromal-derived factor-1 in murine models of liver injury and regeneration.
Article in Liver international : official journal of the International Association for the Study of the Liver, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Systemic inflammatory regulators and risk of acute-on-chronic liver failure: A bidirectional mendelian-randomization study.Frontiers in cell and developmental biology · 2023Article
- Dental stem cells: The role of biomaterials and scaffolds in developing novel therapeutic strategies.World journal of stem cells · 2020Review
- VEGF-sdf1 recruitment of CXCR7+ bone marrow progenitors of liver sinusoidal endothelial cells promotes rat liver regeneration.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Bone marrow-derived mesenchymal stem cells effectively regenerate fibrotic liver in bile duct ligation rat model.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- Advances in hepatic stem/progenitor cell biology.EXCLI journal · 2015Review
- Identification and characterization of circulating variants of CXCL12 from human plasma: effects on chemotaxis and mobilization of hematopoietic stem and progenitor cells.Stem cells and development · 2014Article
- Two-tier regenerative response in liver failure in humans.Virchows Archiv : an international journal of pathology · 2014Article
- Multiple courses of G-CSF in patients with decompensated cirrhosis: consistent mobilization of immature cells expressing hepatocyte markers and exploratory clinical evaluation.Hepatology international · 2013Article
- SCF promotes dental pulp progenitor migration, neovascularization, and collagen remodeling - potential applications as a homing factor in dental pulp regeneration.Stem cell reviews and reports · 2013Article
- Article
- Mild hypothermia does not affect liver regeneration after partial hepatectomy in mice.Liver international : official journal of the International Association for the Study of the Liver · 2009Article
- Foxl1 is a marker of bipotential hepatic progenitor cells in mice.Hepatology (Baltimore, Md.) · 2009Article
- Unlocking the regenerative key: Targeting stem cell factors for bone renewal.Journal of tissue engineeringReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND/
aimsStem cell factor (SCF) and stromal-derived factor-1 (SDF-1) regulate the regenerative response to liver injury, possibly through activation of liver progenitor 'oval' cells and recruitment of circulating, marrow-derived progenitors.
methodsWe performed a detailed analysis of SCF, SDF-1 and oval cell proliferation induced by tyrosinaemia, 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) or liver irradiation in mice by ELISA and immunofluorescence.
resultsLiver injury in the tyrosinaemia mouse is characterized by a dramatic decline in plasma SCF and absence of oval cell proliferation. In contrast, DDC induces bile duct (BD) and oval cell proliferation, and a modest decline in plasma SCF. Focal liver irradiation increases plasma SCF, but not oval cell density. In normal mouse liver, SCF is localized primarily to Kupffer cells, cholangiocytes and arterial smooth muscle, with little or no expression in hepatocytes. However, SCF appears in hepatocyte nuclei after injury, where its function is unknown. In all three models, SDF-1 is expressed exclusively in BD epithelium, indicating that tissue SDF-1 levels are proportional to the total mass of oval cells and cholangiocytes. However, increased plasma levels of SDF-1 in fumaryl acetoacetate hydroxylase-null mice were not accompanied by oval cell proliferation.
conclusionChanges in SCF and SDF-1 varied with the nature of liver injury and were not directly related to oval cell proliferation.
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