ReviewProgress in retinal and eye research2008
Fluid transport phenomena in ocular epithelia.
Review in Progress in retinal and eye research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Trans-conjunctival aqueous humor outflow in glaucomatous patients treated with prostaglandin analogues: an in vivo confocal microscopy study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2014Trial
- A digoxin derivative that potently reduces intraocular pressure: efficacy and mechanism of action in different animal models.American journal of physiology. Cell physiology · 2024Article
- Wireless-Powered Electrical Bandage Contact Lens for Facilitating Corneal Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Targeting Ocular Drug Delivery: An Examination of Local Anatomy and Current Approaches.Bioengineering (Basel, Switzerland) · 2022Review
- Polymodal Sensory Transduction in Mouse Corneal Epithelial Cells.Investigative ophthalmology & visual science · 2020Article
- Immunoresolvent Resolvin D1 Maintains the Health of the Ocular Surface.Advances in experimental medicine and biology · 2019Review
- Altered expression of aquaporin 1 and aquaporin 5 in the cornea after primary blast exposure.Molecular vision · 2019Article
- Mechanisms, imaging and structure of tear film breakup.The ocular surface · 2018Review
- Net Fluorescein Flux Across Corneal Endothelium Strongly Suggests Fluid Transport is due to Electro-osmosis.The Journal of membrane biology · 2016Article
- Expression Profiling of Ascorbic Acid-Related Transporters in Human and Mouse Eyes.Investigative ophthalmology & visual science · 2016Article
- Evaluating the Functionality of Conjunctiva Using a Rabbit Dry Eye Model.Journal of ophthalmology · 2016Article
- Measurement of Crystalline Lens Volume During Accommodation in a Lens Stretcher.Investigative ophthalmology & visual science · 2015Article
- Loss of NHE8 expression impairs ocular surface function in mice.American journal of physiology. Cell physiology · 2015Article
- The aquaporin zero puzzle.Biophysical journal · 2014Review
- Aquaporins in the eye: expression, function, and roles in ocular disease.Biochimica et biophysica acta · 2014Review
- Connexins form functional hemichannels in porcine ciliary epithelium.Experimental eye research · 2014Article
- A contemporary concept of the blood-aqueous barrier.Progress in retinal and eye research · 2013Review
- Electrical signaling in control of ocular cell behaviors.Progress in retinal and eye research · 2012Review
- Spatial and temporal dissociation of AQP4 and Kir4.1 expression during induction of refractive errors.Molecular vision · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
This article discusses three largely unrecognized aspects related to fluid movement in ocular tissues; namely, (a) the dynamic changes in water permeability observed in corneal and conjunctival epithelia under anisotonic conditions, (b) the indications that the fluid transport rate exhibited by the ciliary epithelium is insufficient to explain aqueous humor production, and (c) the evidence for fluid movement into and out of the lens during accommodation. We have studied each of these subjects in recent years and present an evaluation of our data within the context of the results of others who have also worked on electrolyte and fluid transport in ocular tissues. We propose that (1) the corneal and conjunctival epithelia, with apical aspects naturally exposed to variable tonicities, are capable of regulating their water permeabilities as part of the cell-volume regulatory process, (2) fluid may directly enter the anterior chamber of the eye across the anterior surface of the iris, thereby representing an additional entry pathway for aqueous humor production, and (3) changes in lens volume occur during accommodation, and such changes are best explained by a net influx and efflux of fluid.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.