ArticleNeurobiology of learning and memory2008
Olfactory discrimination learning in mice lacking the fragile X mental retardation protein.
Article in Neurobiology of learning and memory, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- A systematic-review of olfactory deficits in neurodevelopmental disorders: From mouse to human.Neuroscience and biobehavioral reviews · 2021Pooled it
- Dysfunctional neural dynamics associated with sensory phenotypes in Fragile X syndrome: insights from mouse models.Journal of neurodevelopmental disorders · 2025Review
- Olfactory dysfunction and altered cortical excitability in the mouse model of Fragile X Syndrome.Biological research · 2025Article
- Anterior piriform cortex dysfunction underlies autism spectrum disorders-related olfactory deficits in Fmr1 conditional deletion mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Altered olfactory responses in Fmr1 KO mice.Scientific reports · 2025Article
- Hyperexcitability in the Olfactory Bulb and Impaired Fine Odor Discrimination in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Mouse models of fragile X-related disorders.Disease models & mechanisms · 2023Review
- Structural and Functional Abnormalities in the Olfactory System of Fragile X Syndrome Models.Frontiers in molecular neuroscience · 2019Review
- Visual Behavior Impairments as an Aberrant Sensory Processing in the Mouse Model of Fragile X Syndrome.Frontiers in behavioral neuroscience · 2019Article
- Cellular distribution of the fragile X mental retardation protein in the mouse brain.The Journal of comparative neurology · 2017Article
- Behavioral and physiological characterization of PKC-dependent phosphorylation in the Grin2a∆PKC mouse.Brain research · 2016Article
- Fragile X mental retardation protein regulates olfactory sensitivity but not odorant discrimination.Chemical senses · 2015Article
- Synaptic NMDA receptor-mediated currents in anterior piriform cortex are reduced in the adult fragile X mouse.Neuroscience · 2012Article
- In vivo neuronal function of the fragile X mental retardation protein is regulated by phosphorylation.Human molecular genetics · 2012Article
- Comprehensive neurocognitive endophenotyping strategies for mouse models of genetic disorders.Progress in neurobiology · 2012Review
- Fragile X syndrome and targeted treatment trials.Results and problems in cell differentiation · 2012Review
- Targeted treatments for fragile X syndrome.Journal of neurodevelopmental disorders · 2011Article
- The fragile X mental retardation protein in circadian rhythmicity and memory consolidation.Molecular neurobiology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
An automated training system was used to compare the behavior of knockout (KO) mice lacking the fragile X mental retardation protein with that of wild-type (WT) mice (C57Bl/6 strain) in the acquisition and retention of olfactory discriminations. KO and WT mice did not differ in the acquisition of a four-stage nose poke shaping procedure. In two separate experiments, mutant mice required substantially more training to acquire a series of novel olfactory discrimination problems than did control mice. The KO mice required significantly more sessions to reach criterion performance, made significantly more errors during training, and more often failed to acquire discriminations. Both KO and WT mice showed similar error patterns when learning novel discriminations and both groups showed evidence of more rapid learning of later discriminations in the problem series. Both groups showed significant long-term memory two or four weeks after training but WT and KO mice did not differ in this regard. A group of well-trained mice were given training on novel odors in sessions limited to 20-80 trials. Memory of these problems at two day delays did not differ between WT and KO mice. Tests using ethyl acetate demonstrated that WT and KO mice had similar odor detection thresholds.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.