ArticleInternational journal of pharmaceutics2008
Freeze drying of peptide drugs self-associated with long-circulating, biocompatible and biodegradable sterically stabilized phospholipid nanomicelles.
Article in International journal of pharmaceutics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Randomized-field microwave-assisted pharmaceutical lyophilization with closed-loop control.Scientific reports · 2025Article
- The Role of Freeze-Drying as a Multifunctional Process in Improving the Properties of Hydrogels for Medical Use.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Synthesis and Evaluation of Clinically Translatable Targeted Microbubbles Using a Microfluidic Device for In Vivo Ultrasound Molecular Imaging.International journal of molecular sciences · 2023Article
- Clinically translatable formulation strategies for systemic administration of nerve-specific probes.Advanced therapeutics · 2021Article
- Lyophilization Serves as an Effective Strategy for Drug Development of the α9α10 Nicotinic Acetylcholine Receptor Antagonist α-Conotoxin GeXIVA[1,2].Marine drugs · 2021Article
- Colonic delivery of vasoactive intestinal peptide nanomedicine alleviates colitis and shows promise as an oral capsule.Nanomedicine (London, England) · 2020Article
- Cytotoxic, Apoptotic and Genotoxic Effects of Lipid-Based and Polymeric Nano Micelles, an In Vitro Evaluation.Toxics · 2017Article
- Vasoactive Intestinal Peptide Nanomedicine for the Management of Inflammatory Bowel Disease.Molecular pharmaceutics · 2017Article
- A new lipid-based nano formulation of vinorelbine.AAPS PharmSciTech · 2014Article
- Recent developments in protein and peptide parenteral delivery approaches.Therapeutic delivery · 2014Article
- Curcumin in VIP-targeted sterically stabilized phospholipid nanomicelles: a novel therapeutic approach for breast cancer and breast cancer stem cells.Drug delivery and translational research · 2013Article
- A novel peptide nanomedicine for treatment of pancreatogenic diabetes.Nanomedicine : nanotechnology, biology, and medicine · 2013Article
- A critical review of lipid-based nanoparticles for taxane delivery.Cancer letters · 2013Review
- Gold nanoparticles - the theranostic challenge for PPPM: nanocardiology application.The EPMA journal · 2013Article
- Protected graft copolymer excipient leads to a higher acute maximum tolerated dose and extends residence time of vasoactive intestinal Peptide significantly better than sterically stabilized micelles.Pharmaceutical research · 2013Article
- Novel, biocompatible, and disease modifying VIP nanomedicine for rheumatoid arthritis.Molecular pharmaceutics · 2013Article
- In vitro and in vivo characterisation of PEG-lipid-based micellar complexes of salmon calcitonin for pulmonary delivery.Pharmaceutical research · 2012Article
- Human pancreatic polypeptide in a phospholipid-based micellar formulation.Pharmaceutical research · 2012Article
- Solubilization of beclomethasone dipropionate in sterically stabilized phospholipid nanomicelles (SSMs): physicochemical and in vitro evaluations.Drug design, development and therapy · 2012Article
- A silica-based pH-sensitive nanomatrix system improves the oral absorption and efficacy of incretin hormone glucagon-like peptide-1.International journal of nanomedicine · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The purpose of this study was to determine optimal lipid concentration range for lyophilization of sterically stabilized phospholipid nanomicelles (SSM) and the freeze drying feasibility of self-associated therapeutic peptide-SSM assemblies. SSM at 5-20 mM 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000) (DSPE-PEG(2000)) were analyzed for particle size and viscosity before and after freeze drying which showed no significant changes (p>0.05). However, a steep increase in viscosity was seen for SSM above 15 mM phospholipid implying micelle-micelle interaction. Greater shrinkage of lyophilized cakes was observed below 10 mM phospholipid while they were more fibrous above 15 mM. Therefore, 10-15 mM DSPE-PEG(2000) was chosen as the optimal phospholipid concentration for lyophilized SSM. When vasoactive intestinal peptide (VIP), glucagon-like peptide 1 (GLP-1) or gastric inhibitory peptide (GIP) (each, 67 microM) was added to SSM (10mM), formulations showed no significant change in particle size, peptide fluorescence and peptide alpha-helicity before and after lyophilization. In conclusion, we found that peptide drug-SSM interactions are conserved during lyophilization.
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