ArticlePLoS biology2008
In vitro whole-genome analysis identifies a susceptibility locus for HIV-1.
Article in PLoS biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 69 citations in OpenAlex.
- Review
- Emerging Role of LY6E in Virus-Host Interactions.Viruses · 2019Review
- CD4-Dependent Modulation of HIV-1 Entry by LY6E.Journal of virology · 2019Article
- Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids.PloS one · 2019Article
- Emerging Role of Lymphocyte Antigen-6 Family of Genes in Cancer and Immune Cells.Frontiers in immunology · 2019Review
- LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step.Nature communications · 2018Article
- Genome-wide scan for commons SNPs affecting bovine leukemia virus infection level in dairy cattle.BMC genomics · 2018Article
- Engaging Ly-6A/Sca-1 triggers lipid raft-dependent and -independent responses in CD4Immunity, inflammation and disease · 2017Article
- Whole genome sequencing of extreme phenotypes identifies variants in CD101 and UBE2V1 associated with increased risk of sexually acquired HIV-1.PLoS pathogens · 2017Article
- The genomic landscape of human cellular circadian variation points to a novel role for the signalosome.eLife · 2017Article
- Interferon-inducible LY6E Protein Promotes HIV-1 Infection.The Journal of biological chemistry · 2017Article
- Coexpression Analysis of Transcriptome on AIDS and Other Human Disease Pathways by Canonical Correlation Analysis.International journal of genomics · 2017Article
- Differences in T cell distribution and CCR5 expression in HIV-positive and HIV-exposed seronegative persons who inject drugs.Medical microbiology and immunology · 2016Article
- A Cellular GWAS Approach to Define Human Variation in Cellular Pathways Important to Inflammation.Pathogens (Basel, Switzerland) · 2016Review
- Associations of common variants in the BST2 region with HIV-1 acquisition in African American and European American people who inject drugs.AIDS (London, England) · 2015Article
- Article
- Mitochondrial DNA variation and virologic and immunological HIV outcomes in African Americans.AIDS (London, England) · 2014Observational
- Understanding human variation in infectious disease susceptibility through clinical and cellular GWAS.PLoS pathogens · 2013Review
- Host genetics of HIV acquisition and viral control.Annual review of medicine · 2013Review
- Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advances in large-scale analysis of human genomic variability provide unprecedented opportunities to study the genetic basis of susceptibility to infectious agents. We report here the use of an in vitro system for the identification of a locus on HSA8q24.3 associated with cellular susceptibility to HIV-1. This locus was mapped through quantitative linkage analysis using cell lines from multigeneration families, validated in vitro, and followed up by two independent association studies in HIV-positive individuals. Single nucleotide polymorphism rs2572886, which is associated with cellular susceptibility to HIV-1 in lymphoblastoid B cells and in primary T cells, was also associated with accelerated disease progression in one of two cohorts of HIV-1-infected patients. Biological analysis suggests a role of the rs2572886 region in the regulation of the LY6 family of glycosyl-phosphatidyl-inositol (GPI)-anchored proteins. Genetic analysis of in vitro cellular phenotypes provides an attractive approach for the discovery of susceptibility loci to infectious agents.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.