ArticleProceedings of the National Academy of Sciences of the United States of America1991
Kinesin is responsible for centrifugal movement of pigment granules in melanophores.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 170 citations in OpenAlex.
- Body Coloration Characterization and Proteomic Analysis of Diurnal Color Variation in FarmedAnimals : an open access journal from MDPI · 2026Article
- High-intensity light disrupts intracellular organelle dynamics via microtubule depolymerization.Scientific reports · 2025Article
- The physical and cellular mechanism of structural color change in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Exploring the mechanisms and impacts of melatonin on fish colouration.Fish physiology and biochemistry · 2023Review
- Enzymatic, morphological, and genotoxic effects of benzo[a]pyrene in rainbow trout (Oncorhynchus mykiss).Environmental science and pollution research international · 2021Article
- Persistent growth of microtubules at low density.Molecular biology of the cell · 2021Article
- Comparative transcriptomics reveals candidate carotenoid color genes in an East African cichlid fish.BMC genomics · 2020Article
- Biochemical regulation of pigment motility in vertebrate chromatophores: a review of physiological color change mechanisms.Current zoology · 2016Article
- A Unique Role for Endothelial Cell Kinesin Light Chain 1, Variant 1 in Leukocyte Transendothelial Migration.The American journal of pathology · 2016Article
- Self-organized optical device driven by motor proteins.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Evidence that myosin activity opposes microtubule-based axonal transport of mitochondria.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- PH-domain-dependent selective transport of p75 by kinesin-3 family motors in non-polarized MDCK cells.Journal of cell science · 2010Article
- Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Switching of membrane organelles between cytoskeletal transport systems is determined by regulation of the microtubule-based transport.The Journal of cell biology · 2007Article
- Polarization-dependent selective transport to the apical membrane by KIF5B in MDCK cells.Developmental cell · 2007Article
- Multiscale trend analysis of microtubule transport in melanophores.Biophysical journal · 2005Article
- Transport of Drosophila fragile X mental retardation protein-containing ribonucleoprotein granules by kinesin-1 and cytoplasmic dynein.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Self-organization of a radial microtubule array by dynein-dependent nucleation of microtubules.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Insulin action on GLUT4 traffic visualized in single 3T3-l1 adipocytes by using ultra-fast microscopy.Molecular biology of the cell · 2001Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kinesin is a mechanochemical ATPase that induces translocation of latex beads along microtubules and microtubule gliding on a glass surface. This protein is thought to be a motor for the movement of membranous organelles in cells. Recently Hollenbeck and Swanson [Hollenbeck, P. J. & Swanson, J. A. (1990) Nature (London) 346, 864-866] showed that kinesin is involved in the positioning of tubular lysosomes in macrophages. However, the role of this protein in the movement of organelles was not yet clear. We used a polyclonal antibody against the kinesin heavy chain that inhibited kinesin-dependent microtubule gliding in vitro to study the role of kinesin in the movement of pigment granules in melanophores of the teleost black tetra (Gymnocorymbus ternetzi). Microinjection of the antibody into cultured melanophores did not produce any specific effect on the aggregation of pigment granules in melanophores, but it did result in a strong dose-dependent inhibition of the dispersion. Immunoblotting of melanophore extracts showed that the kinesin antibody reacted in these cells with a single protein component with a molecular mass of 135 kDa. Thus, kinesin is responsible for the movement of pigment granules from the center to the periphery of the melanophore.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.