ArticleAnalytical chemistry2008
Enhanced fluorescent immunoassays on silver fractal-like structures.
Article in Analytical chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 59 citations in OpenAlex.
- Sandwich type plasmonic platform for MEF using silver fractals.Nanoscale · 2015Article
- Preparation of plasmonic platforms of silver wires on gold mirrors and their application to surface enhanced fluorescence.ACS applied materials & interfaces · 2014Article
- A straightforward immunoassay applicable to a wide range of antibodies based on surface enhanced fluorescence.Journal of fluorescence · 2013Article
- Immunoassays based on surface-enhanced fluorescence using gap-plasmon-tunable Ag bilayer nanoparticle films.Journal of fluorescence · 2013Article
- Spatially selective photonic crystal enhanced fluorescence and application to background reduction for biomolecule detection assays.Optics express · 2011Article
- Plasmonic platforms of self-assembled silver nanostructures in application to fluorescence.Journal of nanophotonics · 2010Article
- A detection instrument for enhanced-fluorescence and label-free imaging on photonic crystal surfaces.Optics express · 2009Article
- Enhanced Fluorescence Emission of Me-ADOTA by Self-Assembled Silver Nanoparticles on a Gold Film.Chemical physics letters · 2009Article
- Metal Enhanced Fluorescence on Silicon Wafer Substrates.Chemical physics letters · 2008Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Using the effect of the fluorescence enhancement in close proximity to metal nanostructures, we have been able to demonstrate ultrasensitive immunoassays suitable for the detection of biomarkers. Silver fractal-like structures have been grown by electrochemical reduction of silver on the surface of glass slides. A model immunoassay was performed on the slide surface with rabbit IgG (antigen) noncovalently immobilized on the slide, and rhodamine red-X-labeled antirabbit IgG conjugate was subsequently bound to the immobilized antigen. The fluorescence signal was measured from the glass-fractal's surface using a confocal microscope, and the images were compared to the images from the same surface not coated with fractals. Our results showed significant enhancement (more than 100-fold) of the signal detected on fractals compared to bare glass. We thus demonstrate that such fractal-like structures can assist in improving the signals from assays used in medical diagnostics, especially those for analytes with molecular weight under 100 kDa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.