ArticleMolecular carcinogenesis2008
Analysis of the expression of biomarkers in urinary bladder cancer using a tissue microarray.
Article in Molecular carcinogenesis, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Proteomic comparison between different tissue preservation methods for identification of promising biomarkers of urothelial bladder cancer.Scientific reports · 2021Article
- L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasiveness.Cell communication and signaling : CCS · 2021Article
- Feature selection with the Fisher score followed by the Maximal Clique Centrality algorithm can accurately identify the hub genes of hepatocellular carcinoma.Scientific reports · 2019Article
- Connexins in cancer: bridging the gap to the clinic.Oncogene · 2019Review
- Insulin-like growth factor-1 receptor expression in upper tract urothelial carcinoma.Virchows Archiv : an international journal of pathology · 2019Article
- Clinical Significance of PTEN Deletion, Mutation, and Loss of PTEN Expression in De Novo Diffuse Large B-Cell Lymphoma.Neoplasia (New York, N.Y.) · 2018Article
- Genetic deletion and pharmacological inhibition of Akt1 isoform attenuates bladder cancer cell proliferation, motility and invasion.European journal of pharmacology · 2015Article
- Connexin 43 expression predicts poor progression-free survival in patients with non-muscle invasive urothelial bladder cancer.Journal of clinical pathology · 2015Article
- Abnormal Protein Glycosylation and Activated PI3K/Akt/mTOR Pathway: Role in Bladder Cancer Prognosis and Targeted Therapeutics.PloS one · 2015Article
- The mouse cyclophosphamide model of bladder pain syndrome: tissue characterization, immune profiling, and relationship to metabotropic glutamate receptors.Physiological reports · 2014Article
- Dysregulation of mammalian target of rapamycin pathway in plasmacytoid variant of urothelial carcinoma of the urinary bladder.Human pathology · 2013Article
- Overexpression of DJ-1 and HSP90α, and loss of PTEN associated with invasive urothelial carcinoma of urinary bladder: Possible prognostic markers.Oncology letters · 2012Article
- Plastin family of actin-bundling proteins: its functions in leukocytes, neurons, intestines, and cancer.International journal of cell biology · 2012Article
- Phosphatidylinositol 3'-kinase, mTOR, and glycogen synthase kinase-3β mediated regulation of p21 in human urothelial carcinoma cells.BMC urology · 2011Article
- Article
- Identification of genes correlated with early-stage bladder cancer progression.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- Molecular genetics of bladder cancer: Emerging mechanisms of tumor initiation and progression.Urologic oncologyReview
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Dysregulation of Akt, PTEN, Drg-1, Cx-26, and L-plastin expression appear to be important in the progression of various cancers. Their expression in bladder cancer has not been well characterized. To assess the expression of these genes and their relationship to the outcome of bladder cancer, we used a bladder cancer tissue microarray (TMA) of 251 transitional cell carcinomas. We quantitated immunohistochemical staining of each protein using both automated and manual methods and correlated the expression levels with the clinicopathologic characteristics of the tumor and patient survival. Overall, the results from both automated and manual analyses were similar. We found a significant correlation between the expression of PTEN, Cx-26 and L-plastin with known clinically important pathologic features of bladder cancer (tumor grade, stage, and growth pattern). Aberrant localization patterns of Cx-26 and Drg-1 were observed in bladder tumors. There was also a significant correlation in expression among pAkt, PTEN, and L-plastin. Although the expression of these genes correlated with factors known to be associated with patient outcome, none of them was an independent predictor of progression-free or overall survival.
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