ArticleJournal of cancer research and clinical oncology2008
ATM in oral carcinogenesis: association with clinicopathological features.
Article in Journal of cancer research and clinical oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- The Neem Limonoid Nimbolide Modulates Key Components of the DNA Damage Response Signalling in Cellular and Animal Models of Oral Squamous Cell Carcinoma.Current pharmaceutical biotechnology · 2025Article
- Downregulation of ATM and BRCA1 Predicts Poor Outcome in Head and Neck Cancer: Implications for ATM-Targeted Therapy.Journal of personalized medicine · 2021Article
- Multidimensional Mutational Profiling of the Indian HNSCC Sub-Population Provides IRAK1, a Novel Driver Gene and Potential Druggable Target.Frontiers in oncology · 2021Article
- Analysis of differentially expressed genes in oral epithelial cells infected with Fusobacterium nucleatum for revealing genes associated with oral cancer.Journal of cellular and molecular medicine · 2021Article
- Hydrogen Sulfide Is Increased in Oral Squamous Cell Carcinoma Compared to Adjacent Benign Oral Mucosae.Anticancer research · 2018Article
- Expression of DNA doublestrand repair proteins in oral leukoplakia and the risk of malignant transformation.Oncology letters · 2018Article
- Prognostic factors in oral and oropharyngeal cancer based on ultrastructural analysis and DNA methylation of the tumor and surgical margin.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Association of ATM Gene Polymorphism with PTC Metastasis in Female Patients.International journal of endocrinology · 2014Article
- DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer.PloS one · 2014Article
- Deficient DNA damage signaling leads to chemoresistance to cisplatin in oral cancer.Molecular cancer therapeutics · 2012Article
- Evaluating the potential of a novel oral lesion exudate collection method coupled with mass spectrometry-based proteomics for oral cancer biomarker discovery.Clinical proteomics · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe ataxia telangiectasia mutated (ATM) gene plays a critical role in DNA damage response. Our aim here was to investigate the expression profile and loss of heterozygosity (LOH) of ATM, as well as their relationships to clinicopathological parameters in oral premalignant lesions (leukoplakia) and primary oral squamous cell carcinoma (OSCC).
methodsImmunohistochemical assay and PCR were performed to detect the expression profile and LOH at D11S2179 of ATM. The association between clinicopathological parameters and the changes of ATM was statistically analyzed.
resultsATM protein levels were higher in oral leukoplakia than those in normal controls, while the expressions of ATM protein had a versatile tendency in OSCC: 10 samples (31.25%) showed increased ATM protein levels than those observed in normal tissues, 12 samples (37.50%) had the same protein levels as the normal tissues, and 10 samples (31.25%) showed reduced or absent ATM levels. The patients with reduced/absent ATM expression had more poorly-differentiated situation as well as the tendency for lymph node metastasis. Most interestingly, 50% of these reduced cases were younger than 50 years old. PCR for LOH assay displayed that none of the samples from oral leukoplakia had abnormal changes in D11S2179, while three samples (9.38%) of OSCC showed loss of heterozygosity, and two samples (6.25%) with microsatellite instability.
conclusionsThese findings suggest that overexpression of ATM may be one of the early events in the carcinogenesis of OSCC. ATM might be a candidate biomarker for diagnosis and prognosis in OSCC, as well as a possible genetic marker for early-onset OSCC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.