Trial reportEnvironmental health perspectives2008
Dental amalgam exposure and urinary mercury levels in children: the New England Children's Amalgam Trial.
Trial report in Environmental health perspectives, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Dental composites and amalgam and physical development in children.Journal of dental research · 2012Trial
- Dental composite restorations and neuropsychological development in children: treatment level analysis from a randomized clinical trial.Neurotoxicology · 2012Trial
- Dental composite restorations and psychosocial function in children.Pediatrics · 2012Trial
- Immune function effects of dental amalgam in children: a randomized clinical trial.Journal of the American Dental Association (1939) · 2008Trial
- Human biomonitoring in support of the Minamata Convention: a case of phasing out dental amalgam.Environmental health : a global access science source · 2026Article
- The association of auditory function measures with low-level methylmercury from oceanic fish consumption and mercury vapor from amalgam: The Seychelles Child Development Study Nutrition 1 Cohort.Neurotoxicology · 2023Article
- Prenatal exposure to mercury in relation to infant infections and respiratory symptoms in the New Hampshire Birth Cohort Study.Environmental research · 2019Article
- Mercury in Children: Current State on Exposure through Human Biomonitoring Studies.International journal of environmental research and public health · 2017Review
- Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice.Environmental health perspectives · 2016Article
- Dental amalgam exposure can elevate urinary mercury concentrations in children.International dental journal · 2016Article
- Prenatal exposure to dental amalgam in the Seychelles Child Development Nutrition Study: associations with neurodevelopmental outcomes at 9 and 30 months.Neurotoxicology · 2012Article
- Prenatal exposure to dental amalgam: evidence from the Seychelles Child Development Study main cohort.Journal of the American Dental Association (1939) · 2011Article
- Neurodevelopmental outcomes at 5 years in children exposed prenatally to maternal dental amalgam: the Seychelles Child Development Nutrition Study.Neurotoxicology and teratologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundUrinary mercury (U-Hg) excretion is a commonly used biomarker for mercury exposure from dental amalgam restorations.
objectivesOur goal was to determine the most efficient measure of dental amalgam exposure for use in analyses concerning U-Hg in children.
methodsWe analyzed time-sensitive longitudinal amalgam exposure data in children randomized to amalgam restorations (n = 267) during the 5-year New England Children's Amalgam Trial. We calculated 8 measures of amalgam, evaluating current versus cumulative exposure, teeth versus surfaces, and total versus posterior occlusal amalgams. Urine samples collected during follow-up years 3-5 were analyzed for mercury excretion. Multivariate models for current and cumulative U-Hg excretion estimated associations between exposures and U-Hg.
resultsAt the end of follow-up, the average (+/- SD) cumulative exposure was 10.3 +/- 6.1 surfaces and 5.7 +/- 2.9 teeth ever filled with amalgam, corresponding to 30 +/- 21 surface-years. Amalgam measures and U-Hg were moderately correlated. Of amalgam exposure measures, the current total of amalgam surfaces was the most robust predictor of current U-Hg, whereas posterior occlusal surface-years was best for cumulative U-Hg. In multivariate models, each additional amalgam surface present was associated with a 9% increase in current U-Hg, and each additional posterior occlusal surface-year was associated with a 3% increase in cumulative U-Hg excretion (p < 0.001).
conclusionsOne single measure of amalgam exposure is insufficient. Studies of cumulative effects of mercury from amalgam exposure in children are likely to have improved validity and precision if time-sensitive amalgam exposure measures are used. In contrast, simple counts of current amalgam fillings are adequate to capture amalgam-related current U-Hg.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.