ArticleEnvironmental health perspectives2008
Perturbation of organogenesis by the herbicide atrazine in the amphibian Xenopus laevis.
Article in Environmental health perspectives, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 69 citations in OpenAlex.
- [Open experiment: QuEChERS combined with fluorescence derivatization for the detection of atrazine and its effect on enzyme activity].Se pu = Chinese journal of chromatography · 2025Article
- Developmental regulation of cellular metabolism is required for intestinal elongation and rotation.Development (Cambridge, England) · 2024Article
- Why We Will Continue to Lose Our Battle with Cancers If We Do Not Stop Their Triggers from Environmental Pollution.International journal of environmental research and public health · 2021Review
- A novel mechanism underlies atrazine toxicity in quails (Coturnix Coturnix coturnix): triggering ionic disorder via disruption of ATPases.Oncotarget · 2016Article
- The chemopreventive potential of lycopene against atrazine-induced cardiotoxicity: modulation of ionic homeostasis.Scientific reports · 2016Article
- Frogs as integrative models for understanding digestive organ development and evolution.Seminars in cell & developmental biology · 2016Review
- Atrazine affects phosphoprotein and protein expression in MCF-10A human breast epithelial cells.International journal of molecular sciences · 2014Article
- Sublethal effects of atrazine on embryo-larval development of Rhinella arenarum (Anura: Bufonidae).Ecotoxicology (London, England) · 2012Article
- Atrazine-induced apoptosis of splenocytes in BALB/C mice.BMC medicine · 2011Article
- Low levels of the herbicide atrazine alter sex ratios and reduce metamorphic success in Rana pipiens tadpoles raised in outdoor mesocosms.Environmental health perspectives · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExposure to anthropogenic chemicals during development can disrupt the morphogenesis of organ systems. Use of the herbicide atrazine has been debated in recent years because of its implicated, but poorly characterized, effects on vertebrates. Previous studies primarily examined the effects of atrazine exposure during metamorphosis or early developmental stages of amphibians.
objectivesWe sought to identify and characterize the susceptibility during the often-overlooked developmental stage of organ morphogenesis.
methodsWe used a static renewal experimental treatment to investigate the effects of 10, 25, and 35 mg/L atrazine from early organ morphogenesis through the onset of tadpole feeding in the aquatic amphibian model system, Xenopus laevis. We quantified malformations of the body axis, heart, and intestine, as well as apoptosis in the midbrain and pronephric kidney.
resultsWe found a significant dose-dependent increase in the percentage of atrazine-exposed tadpoles with malformations of multiple tissues including the main body axis, circulatory system, kidney, and digestive system. Incidence of apoptotic cells also increased in the both midbrain and kidney of atrazine-exposed tadpoles.
conclusionsOur results demonstrate that acute atrazine exposure (10-35 mg/L for < or = 48 hr) during early organ morphogenesis disrupts proper organ development in an amphibian model system. The concurrent atrazine-induced apoptosis in the pronephric kidney and midbrain begins to elucidate a mechanism by which atrazine may disrupt developmental processes in nontarget organisms.
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