ArticleMediators of inflammation2007
Protecting effects of dexamethasone on thymus of rats with severe acute pancreatitis.
Article in Mediators of inflammation, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- AcanthopanaxMediators of inflammation · 2016Article
- Vasoactive intestinal peptide promotes gut barrier function against severe acute pancreatitis.Molecular biology reports · 2012Article
- Study of dexamethasone, baicalin and octreotide on brain injury of rats with severe acute pancreatitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Effects of dexamethasone and Salvia miltiorrhizae on the small intestine and immune organs of rats with severe acute pancreatitis.Inflammation · 2010Article
- Baicalin protects thymus of rats with severe acute pancreatitis.Inflammation · 2010Article
- Influence of dexamethasone on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Article
- Effects of Salvia miltiorrhizae on ICAM-1, TLR4, NF-kappaB and Bax proteins expression in multiple organs of rats with severe acute pancreatitis or obstructive jaundice.Inflammation · 2009Article
- Protective effect of Radix Astragali injection on immune organs of rats with obstructive jaundice and its mechanism.World journal of gastroenterology · 2009Article
- Protection of Salvia miltiorrhizae to the spleen and thymus of rats with severe acute pancreatitis or obstructive jaundice.Mediators of inflammation · 2009Article
- Influence of dexamethasone on mesenteric lymph node of rats with severe acute pancreatitis.World journal of gastroenterology · 2008Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo study the protecting effects of dexamethasone on thymus of rats with severe acute pancreatitis (SAP).
methodsThe SAP rats were randomly assigned to the model group and dexamethasone-treated group, the other normal healthy rats were assigned to the sham operation group. The rat survival, thymus pathological changes, apoptotic index, as well as expression levels of NF-kappaB, P-selectin, Bax, Bcl-2, and Caspase-3 protein of all groups were observed, respectively, at 3 hours, 6 hours, and 12 hours. The contents of amylase and endotoxin in plasma as well as the contents of TNF-alpha, PLA2, and NO in serum were determined.
resultsThere was no marked difference between the model group and treated group in survival. The contents of different indexes in blood of treated group were lower than those of the model group to various degrees at different time points. The thymus pathological score was lower in treated group than in model group at 12 hours. The treated group in Caspase-3 protein expression of thymus significantly exceeded the model group at 12 hours. The apoptotic index was significantly higher in treated group than in model group.
conclusionDexamethasone has protecting effects on thymus of SAP rats.
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