ArticleMolecular biology of the cell2008
p204 protein overcomes the inhibition of core binding factor alpha-1-mediated osteogenic differentiation by Id helix-loop-helix proteins.
Article in Molecular biology of the cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- The NRF2/ID2 Axis in Vascular Smooth Muscle Cells: Novel Insights into the Interplay between Vascular Calcification and Aging.Aging and disease · 2024Article
- Non-coding RNAs in ossification of spinal ligament.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2021Review
- The interferon-inducible protein p202 promotes osteogenesis in mouse bone marrow stromal cells.Bioscience reports · 2018Article
- The microRNA-10a/ID3/RUNX2 axis modulates the development of Ossification of Posterior Longitudinal Ligament.Scientific reports · 2018Article
- p204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice.EBioMedicine · 2018Article
- STING Contributes to Abnormal Bone Formation Induced by Deficiency of DNase II in Mice.Arthritis & rheumatology (Hoboken, N.J.) · 2017Article
- Contribution of Inhibitor of DNA Binding/Differentiation-3 and Endocrine Disrupting Chemicals to Pathophysiological Aspects of Chronic Disease.BioMed research international · 2017Review
- Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Regulatory roles of interferon-inducible protein 204 on differentiation and vasculogenic activity of endothelial progenitor cells.Stem cell research & therapy · 2016Article
- Different Roles of GRP78 on Cell Proliferation and Apoptosis in Cartilage Development.International journal of molecular sciences · 2015Article
- The roles of interferon-inducible p200 family members IFI16 and p204 in innate immune responses, cell differentiation and proliferation.Genes & diseases · 2015Article
- Explore on the effect of ATF6 on cell growth and apoptosis in cartilage development.Histochemistry and cell biology · 2014Article
- XBP1S, a BMP2-inducible transcription factor, accelerates endochondral bone growth by activating GEP growth factor.Journal of cellular and molecular medicine · 2014Article
- IRE1a constitutes a negative feedback loop with BMP2 and acts as a novel mediator in modulating osteogenic differentiation.Cell death & disease · 2014Article
- XBP1S associates with RUNX2 and regulates chondrocyte hypertrophy.The Journal of biological chemistry · 2012Article
- Effect of Id1 knockdown on formation of osteolytic bone lesions by prostate cancer PC3 cells in vivo.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2012Article
- Spatial segregation of BMP/Smad signaling affects osteoblast differentiation in C2C12 cells.PloS one · 2011Article
- The p200 family protein p204 as a modulator of cell proliferation and differentiation: a brief survey.Cellular and molecular life sciences : CMLS · 2010Review
- miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1.The Journal of biological chemistry · 2009Article
- p204, a p200 family protein, as a multifunctional regulator of cell proliferation and differentiation.Cytokine & growth factor reviewsReview
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Id proteins play important roles in osteogenic differentiation; however, the molecular mechanism remains unknown. In this study, we established that inhibitor of differentiation (Id) proteins, including Id1, Id2, and Id3, associate with core binding factor alpha-1 (Cbfa1) to cause diminished transcription of the alkaline phosphatase (ALP) and osteocalcin (OCL) gene, leading to less ALP activity and osteocalcin (OCL) production. Id acts by inhibiting the sequence-specific binding of Cbfa1 to DNA and by decreasing the expression of Cbfa1 in cells undergoing osteogenic differentiation. p204, an interferon-inducible protein that interacts with both Cbfa1 and Id2, overcame the Id2-mediated inhibition of Cbfa1-induced ALP activity and OCL production. We show that 1) p204 disturbed the binding of Id2 to Cbfa1 and enabled Cbfa1 to bind to the promoters of its target genes and 2) that p204 promoted the translocation from nucleus to the cytoplasm and accelerated the degradation of Id2 by ubiquitin-proteasome pathway during osteogenesis. Nucleus export signal (NES) of p204 is required for the p204-enhanced cytoplasmic translocation and degradation of Id2, because a p204 mutant lacking NES lost these activities. Together, Cbfa1, p204, and Id proteins form a regulatory circuit and act in concert to regulate osteoblast differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.