ArticleGenetics2008
Characterization of Japanese quail yellow as a genomic deletion upstream of the avian homolog of the mammalian ASIP (agouti) gene.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 102 citations in OpenAlex.
- Photobleaching shapes the expression of plumage phenotypes.Biology open · 2026Article
- Plumage polymorphism in the black sparrowhawk (Accipiter melanoleucus) is strongly associated with the expression level of agouti signaling protein.The Journal of heredity · 2025Article
- Transcriptomic and Metabolomic Analyses Reveal Molecular Regulatory Networks for Pigmentation Deposition in Sheep.International journal of molecular sciences · 2024Article
- Identification of Differentially Expressed Genes and microRNAs in the Gray and White Feather Follicles of Shitou Geese.Animals : an open access journal from MDPI · 2024Article
- Genetic Basis and Evolution of Structural Color Polymorphism in an Australian Songbird.Molecular biology and evolution · 2024Article
- An enhancer ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- A large deletion at the cortex locus eliminates butterfly wing patterning.G3 (Bethesda, Md.) · 2022Article
- Signatures of mitonuclear coevolution in a warbler species complex.Nature communications · 2021Article
- Article
- Selection on a small genomic region underpins differentiation in multiple color traits between two warbler species.Evolution letters · 2020Article
- A quantitative trait locus on chromosome 2 was identified that accounts for a substantial proportion of phenotypic variance of the yellow plumage color in chicken.Poultry science · 2020Article
- Genome-wide genetic structure and selection signatures for color in 10 traditional Chinese yellow-feathered chicken breeds.BMC genomics · 2020Article
- Transcriptome Reveals Multi Pigmentation Genes Affecting Dorsoventral Pattern in Avian Body.Frontiers in cell and developmental biology · 2020Article
- Feather follicles transcriptome profiles in Bashang long-tailed chickens with different plumage colors.Genes & genomics · 2019Article
- Article
- Two new structural mutations in the 5' region of the ASIP gene cause diluted feather color phenotypes in Japanese quail.Genetics, selection, evolution : GSE · 2019Article
- Genomic regions of speciation and adaptation among three species of grouse.Scientific reports · 2019Article
- Nonsense mutation in PMEL is associated with yellowish plumage colour phenotype in Japanese quail.Scientific reports · 2018Article
- Gyrfalcons Falco rusticolus adjust CTNS expression to food abundance: a possible contribution to cysteine homeostasis.Oecologia · 2017Article
- Article
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ASIP is an important pigmentation gene responsible for dorsoventral and hair-cycle-specific melanin-based color patterning in mammals. We report some of the first evidence that the avian ASIP gene has a role in pigmentation. We have characterized the genetic basis of the homozygous lethal Japanese quail yellow mutation as a >90-kb deletion upstream of ASIP. This deletion encompasses almost the entire coding sequence of two upstream loci, RALY and EIF2B, and places ASIP expression under control of the RALY promoter, leading to the presence of a novel transcript. ASIP mRNA expression was upregulated in many tissues in yellow compared to wild type but was not universal, and consistent differences were not observed among skins of yellow and wild-type quail. In a microarray analysis on developing feather buds, the locus with the largest downregulation in yellow quail was SLC24A5, implying that it is regulated by ASIP. Finally, we document the presence of ventral skin-specific isoforms of ASIP mRNA in both wild-type quails and chickens. Overall, there are remarkable similarities between yellow in quail and lethal yellow in mouse, which involve a deletion in a similar genomic position. The presence of ventral-specific ASIP expression in birds shows that this feature is conserved across vertebrates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.