ArticleGenetics2008
Recessive black is allelic to the yellow plumage locus in Japanese quail and associated with a frameshift deletion in the ASIP gene.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 71 citations in OpenAlex.
- Plumage polymorphism in the black sparrowhawk (Accipiter melanoleucus) is strongly associated with the expression level of agouti signaling protein.The Journal of heredity · 2025Article
- The Role of Two Tyrosinase-Like Glycoenzymes in Defining the Final Hue of Parrot Plumage.Pigment cell & melanoma research · 2025Article
- Genome-Wide Association Studies Reveal Candidate Genes Associated with Pigmentation Patterns of Single Feathers of Tianfu Nonghua Ducks.Animals : an open access journal from MDPI · 2023Article
- Selective sweeps on different pigmentation genes mediate convergent evolution of island melanism in two incipient bird species.PLoS genetics · 2022Article
- A 13.42-kb tandem duplication at the ASIP locus is strongly associated with the depigmentation phenotype of non-classic Swiss markings in goats.BMC genomics · 2022Article
- Sex Identification of Feather Color in Geese and the Expression of Melanin in Embryonic Dorsal Skin Feather Follicles.Animals : an open access journal from MDPI · 2022Article
- Variants at the ASIP locus contribute to coat color darkening in Nellore cattle.Genetics, selection, evolution : GSE · 2021Article
- Atypical Genotypes for CanineGenes · 2020Article
- Construction of MC1R and ASIP Eukaryotic Expression Vector and its Regulation of Plumage Color in Japanese Quail (The journal of poultry science · 2019Article
- Two new structural mutations in the 5' region of the ASIP gene cause diluted feather color phenotypes in Japanese quail.Genetics, selection, evolution : GSE · 2019Article
- Nonsense mutation in PMEL is associated with yellowish plumage colour phenotype in Japanese quail.Scientific reports · 2018Article
- Polymorphisms in MC1R and ASIP Genes are Associated with Coat Color Variation in the Arabian Camel.The Journal of heredity · 2018Article
- Mutations in different pigmentation genes are associated with parallel melanism in island flycatchers.Proceedings. Biological sciences · 2016Article
- Candidate Gene Analysis Suggests Untapped Genetic Complexity in Melanin-Based Pigmentation in Birds.The Journal of heredity · 2016Article
- Fine mapping of complex traits in non-model species: using next generation sequencing and advanced intercross lines in Japanese quail.BMC genomics · 2012Article
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- Agouti revisited: transcript quantification of the ASIP gene in bovine tissues related to protein expression and localization.PloS one · 2012Article
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- Identification of genes related to white and black plumage formation by RNA-Seq from white and black feather bulbs in ducks.PloS one · 2012Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recessive black plumage mutation in the Japanese quail (Coturnix japonica) is controlled by an autosomal recessive gene (rb) and displays a blackish-brown phenotype in the recessive homozygous state (rb/rb). A similar black coat color phenotype in nonagouti mice is caused by an autosomal recessive mutation at the agouti locus. An allelism test showed that wild type and mutations for yellow, fawn-2, and recessive black in Japanese quail were multiple alleles (*N, *Y, *F2, and *RB) at the same locus Y and that the dominance relationship was Y*F2 > Y*Y > Y*N > Y*RB. A deletion of 8 bases was found in the ASIP gene in the Y*RB allele, causing a frameshift that changed the last six amino acids, including a cysteine residue, and removed the normal stop codon. Since the cysteine residues at the C terminus are important for disulphide bond formation and tertiary structure of the agouti signaling protein, the deletion is expected to cause a dysfunction of ASIP as an antagonist of alpha-MSH in the Y*RB allele. This is the first evidence that the ASIP gene, known to be involved in coat color variation in mammals, is functional and has a similar effect on plumage color in birds.
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