Evidence map›Paper›PMID 18287318›Full record

ArticleJournal of clinical microbiology2008

Increased sporulation rate of epidemic Clostridium difficile Type 027/NAP1.

Thomas Akerlund, Ingela Persson, Magnus Unemo, Torbjörn Norén, Bo Svenungsson, Marlene Wullt, Lars G Burman

Abstract read
In one paragraph

Article in Journal of clinical microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed.

  1. Variety ofGerms · 2026
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  3. A Colombian strain ofVirulence · 2025
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  6. Prevalence of toxigenicThe Libyan journal of medicine · 2024
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  7. "Antibiotics (Basel, Switzerland) · 2024
    Article
  8. Pathogens (Basel, Switzerland) · 2024
    Review
  9. Advances in diagnostic assays forFrontiers in cellular and infection microbiology · 2024
    Review
  10. Clostridioides difficile Sporulation.Advances in experimental medicine and biology · 2024
    Review
  11. Article
  12. Insights into the Evolving Epidemiology ofAntibiotics (Basel, Switzerland) · 2023
    Review
  13. Article
  14. Article
  15. Review
  16. Opportunities for Nanomedicine inAntibiotics (Basel, Switzerland) · 2021
    Review
  17. Temporal Variations in Patterns ofAntibiotics (Basel, Switzerland) · 2021
    Article
  18. Article
  19. Article
  20. Production ofFrontiers in cellular and infection microbiology · 2021
    Article

50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thomas AkerlundSwedish Institute for Infectious Disease Control, Department of Bacteriology, SE-171 82, Solna, Sweden. Thomas.Akerlund@smi.ki.se
Ingela Persson
Magnus Unemo
Torbjörn Norén
Bo Svenungsson
Marlene Wullt
Lars G Burman

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clostridium difficile PCR ribotype 027 comprised 0.2% of a collection of Swedish isolates in 1997-2001 (3 of 1,325 isolates). These isolates had lower moxifloxacin MICs than the epidemic type 027 isolates, but they had the same tcdC sequence and toxin yield. Type 027 produced 3- to 13-fold more toxin than did major Swedish types. One epidemic strain (027/NAP1a) sporulated more than did other type 027 isolates, a feature that should contribute to its survival and spread.

Indexed as

Disease OutbreaksAged, 80 and overAnti-Bacterial AgentsAza CompoundsBacterial ProteinsClostridioides difficileEnterocolitis, PseudomembranousFluoroquinolonesHumansMicrobial Sensitivity TestsMiddle AgedMoxifloxacinQuinolinesRepressor ProteinsRibotypingSpores, BacterialAnti-Bacterial AgentsAza CompoundsBacterial ProteinsFluoroquinolonesMoxifloxacinQuinolinesRepressor ProteinsTcdC protein, Clostridium difficile

Identifiers

PMID18287318
PMCPMC2292905

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.