ArticleJournal of virology2008
Proteomic studies reveal coordinated changes in T-cell expression patterns upon infection with human immunodeficiency virus type 1.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
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Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Transcriptomic meta-analysis identifies gene expression characteristics in various samples of HIV-infected patients with nonprogressive disease.Journal of translational medicine · 2017Pooled it
- Comparative Analysis of Differential Cellular Transcriptome and Proteome Regulation by HIV-1 and HIV-2 Pseudovirions in the Early Phase of Infection.International journal of molecular sciences · 2023Article
- Landscape of T Cells Transcriptional and Metabolic Modules During HIV Infection Based on Weighted Gene Co-expression Network Analysis.Frontiers in genetics · 2021Article
- Block-And-Lock Strategies to Cure HIV Infection.Viruses · 2020Review
- A Pathogen and a Non-pathogen Spotted Fever GroupFrontiers in cellular and infection microbiology · 2019Article
- Understanding Oxidative Stress inViruses · 2018Article
- Upregulation of Glucose Uptake and Hexokinase Activity of Primary Human CD4+ T Cells in Response to Infection with HIV-1.Viruses · 2018Article
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- HIV-1 transgenic rats display mitochondrial abnormalities consistent with abnormal energy generation and distribution.Journal of neurovirology · 2016Article
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- Inhibition of HIV-1 reactivation by a telomerase-derived peptide in a HSP90-dependent manner.Scientific reports · 2016Article
- Functional characterization and proteomic analysis of the nucleocapsid protein of porcine deltacoronavirus.Virus research · 2015Article
- Intracellular expression of Tat alters mitochondrial functions in T cells: a potential mechanism to understand mitochondrial damage during HIV-1 replication.Retrovirology · 2015Article
- Proteomics in the investigation of HIV-1 interactions with host proteins.Proteomics. Clinical applications · 2015Review
- Candidate prioritization for low-abundant differentially expressed proteins in 2D-DIGE datasets.BMC bioinformatics · 2015Article
- Proteomic profiling of SupT1 cells reveal modulation of host proteins by HIV-1 Nef variants.PloS one · 2015Article
- Article
- Changes in the cellular proteins of A549 infected with hepatitis E virus by proteomics analysis.BMC veterinary research · 2014Article
- Proteomics analysis of the DF-1 chicken fibroblasts infected with avian reovirus strain S1133.PloS one · 2014Article
- Mass spectrometry-based proteomic approaches for discovery of HIV-host interactions.Future virology · 2014Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
We performed an extensive two-dimensional differential in-gel electrophoresis proteomic analysis of the cellular changes in human T cells upon human immunodeficiency virus type 1 (HIV-1) infection. We detected 2,000 protein spots, 15% of which were differentially expressed at peak infection. A total of 93 proteins that changed in relative abundance were identified. Of these, 27 were found to be significantly downregulated and 66 were upregulated at peak HIV infection. Early in infection, only a small group of proteins was changed. A clear and consistent program of metabolic rerouting could be seen, in which glycolysis was downregulated and mitochondrial oxidation enhanced. Proteins that participate in apoptotic signaling were also significantly influenced. Apart from these changes, the virus also strongly influenced levels of proteins involved in intracellular transport. These and other results are discussed in light of previous microarray and proteomic studies regarding the impact of HIV-1 infection on cellular mRNA and protein content.
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