ArticleProceedings of the National Academy of Sciences of the United States of America2008
Arabidopsis LEAFY COTYLEDON2 induces maturation traits and auxin activity: Implications for somatic embryogenesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers.
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156 citing papers in PubMed, 299 citations in OpenAlex.
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- Molecular Mechanisms of Programmed Cell Death During Somatic Embryo Detachment from Callus in Indirect Somatic Embryogenesis.International journal of molecular sciences · 2026Review
- A pangenome-based approach reveals genes associated with polyploidy and apomixis in Eragrostis curvula.The plant genome · 2026Article
- Integrated transcriptomic and metabolomic analyses identify OsCGT as essential for C-glycosyl flavone biosynthesis in OsDET1-mutant rice seeds.BMC plant biology · 2026Article
- Single-cell analyses identify the ginseng embryonic protoderm as a native compartment for high-efficiency ginsenoside production.Nature communications · 2026Article
- Cell-specific dedifferentiation inbioRxiv : the preprint server for biology · 2026Article
- The transcription factor LEC2 as an epigenetic regulator of plant totipotency: from Arabidopsis to crop improvement.Journal of applied genetics · 2026Review
- Cell cycle in plant development and reprogramming.Development (Cambridge, England) · 2026Review
- Unravelling the predominant genetic paths for asexual reproduction in Kalanchoe.Nature plants · 2026Article
- LEC2, a key player for cell totipotency in somatic embryogenesis and plant regeneration.Functional & integrative genomics · 2026Article
- The multifaceted role of gibberellins in somatic embryogenesis: fromFrontiers in plant science · 2026Review
- MONOPTEROS isoform MP11ir plays a role during somatic embryogenesis in Arabidopsis thaliana.Plant physiology · 2025Article
- Rational design of induced regeneration via somatic embryogenesis in the absence of exogenous phytohormones.The Plant cell · 2025Article
- Cell death-inducing DNA fragmentation factor alpha (DFFA)-like effectors (CIDEs) improve lipid droplet (LD) formation and oil accumulation in plant tissues.Plant biotechnology journal · 2025Article
- Exploring potential strategies for haploid induction based on double fertilization in plants.Plant biotechnology journal · 2025Review
- The characterization of the LEAFY COTYLEDON 2 activation domains reveals its conserved dual mode of action in flowering plants.The Plant journal : for cell and molecular biology · 2025Article
- From root to embryogenic transition: WOX5 reprograms plant somatic cells via auxin-mediated pathways.BMC plant biology · 2025Article
- LEC2 induces somatic cell reprogramming through epigenetic activation of plant cell totipotency regulators.Nature communications · 2025Article
- Excessive leaf oil modulates the plant abiotic stress response via reduced stomatal aperture in tobacco (Nicotiana tabacum).The Plant journal : for cell and molecular biology · 2025Article
- Application of Developmental Regulators for Enhancing Plant Regeneration and Genetic Transformation.Plants (Basel, Switzerland) · 2024Review
96 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
LEAFY COTYLEDON2 (LEC2) is a central regulator of embryogenesis sufficient to induce somatic cells to form embryos when expressed ectopically. Here, we analyze the cellular processes induced by LEC2, a B3 domain transcription factor, that may underlie its ability to promote somatic embryogenesis. We show auxin-responsive genes are induced after LEC2 activation in seedlings. Genes encoding enzymes involved in auxin biosynthesis, YUC2 and YUC4, are activated within 1 h after induction of LEC2 activity, and YUC4 appears to be a direct transcriptional target of LEC2. We also show ectopic LEC2 expression induces accumulation of seed storage protein and oil bodies in vegetative and reproductive organs, events that normally occur during the maturation phase of embryogenesis. Furthermore, LEC2 activates seed protein genes before an increase in RNAs encoding LEC1 or FUS3 is observed. Thus, LEC2 causes rapid changes in auxin responses and induces cellular differentiation characteristic of the maturation phase. The relevance of these changes to the ability of LEC2 to promote somatic embryogenesis is discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.