ArticleGlia2008
The ABCA1 cholesterol transporter associates with one of two distinct dystrophin-based scaffolds in Schwann cells.
Article in Glia, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- PMP22 Regulates Cholesterol Trafficking and ABCA1-Mediated Cholesterol Efflux.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Dystrophin Dp116: A yet to Be Investigated Product of the Duchenne Muscular Dystrophy Gene.Genes · 2017Review
- Absence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca2+, Reactive Oxygen Species, and Nitric Oxide in the Development of Muscular Dystrophy.Physiological reviews · 2016Review
- LXR Agonism Upregulates the Macrophage ABCA1/Syntrophin Protein Complex That Can Bind ApoA-I and Stabilized ABCA1 Protein, but Complex Loss Does Not Inhibit Lipid Efflux.Biochemistry · 2015Article
- MAL overexpression leads to disturbed expression of genes that influence cytoskeletal organization and differentiation of Schwann cells.ASN neuro · 2014Article
- Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling.The Journal of biological chemistry · 2013Article
- Drp2 and periaxin form Cajal bands with dystroglycan but have distinct roles in Schwann cell growth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Article
- Glia unglued: how signals from the extracellular matrix regulate the development of myelinating glia.Developmental neurobiology · 2011Review
- MMP2-9 cleavage of dystroglycan alters the size and molecular composition of Schwann cell domains.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Biological role of dystroglycan in Schwann cell function and its implications in peripheral nervous system diseases.Journal of biomedicine & biotechnology · 2010Review
- A laminin-2, dystroglycan, utrophin axis is required for compartmentalization and elongation of myelin segments.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Dystrophin and utrophin isoforms are expressed in glia, but not neurons, of the avian parasympathetic ciliary ganglion.Brain research · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Cytoskeletal scaffolding complexes help organize specialized membrane domains with unique functions on the surface of cells. In this study, we define the scaffolding potential of the Schwann cell dystrophin glycoprotein complex (DGC) by establishing the presence of four syntrophin isoforms, (alpha1, beta1, beta2, and gamma2), and one dystrobrevin isoform, (alpha-dystrobrevin-1), in the abaxonal membrane. Furthermore, we demonstrate the existence of two separate DGCs in Schwann cells that divide the abaxonal membrane into spatially distinct domains, the DRP2/periaxin rich plaques and the Cajal bands that contain Dp116, utrophin, alpha-dystrobrevin-1 and four syntrophin isoforms. Finally, we show that the two different DGCs can scaffold unique accessory molecules in distinct areas of the Schwann cell membrane. Specifically, the cholesterol transporter ABCA1, associates with the Dp116/syntrophin complex in Cajal bands and is excluded from the DRP2/periaxin rich plaques.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.